SCHEMBL10338201

SCHEMBL10338201

C/C=C/Cc1c(Oc2ccc(F)c(-c3ncccn3)c2C/C=C/C)ccc(F)c1-c1ncccn1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA2 P47869 1/20 0.32
KDM4E B2RXH2 1/20 0.30
FFAR1 O14842 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10338203 0.79 ALOX5AP (0.31)
SCHEMBL10338205 0.79 ALOX5AP (0.31)
SCHEMBL10338204 0.65 CYP1A2 (0.36) KDM4EFFAR1
SCHEMBL11058986 0.63 MAPT (0.34)
SCHEMBL11058993 0.63 MAPT (0.34)
SCHEMBL14886180 0.62 ACHE (0.44) GABRG2GABRB3GABRA2
SCHEMBL12578987 0.62 RAB9A (0.41) GABRG2GABRB3
SCHEMBL5073292 0.61 SLC6A4 (0.47)
SCHEMBL23037266 0.60 HSP90AA1 (0.33)
SCHEMBL23037268 0.60 HSP90AA1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2019364-A None JP disclosed
JP-H0219364-A ESTER DERIVATIVE OF ALPHA-METHYLALLYLFLUOROPYRIMIDINYLPHENOLS AND LIQUID CRYSTAL COMPOSITION THEREOF CHISSO CORP 1990-01-23 JP disclosed