Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10338069 | 0.85 | POLB (0.54) | KMT2APOLBSMN1; SMN2HTTPTPN1 | |
| SCHEMBL10787661 | 0.69 | XDH (0.79) | — | |
| SCHEMBL29289348 | 0.68 | GDA (0.42) | POLBSMN1; SMN2LMNARAB9AALDH1A1 | |
| SCHEMBL18224773 | 0.67 | CYP3A4 (0.55) | KMT2APOLBSMN1; SMN2HTTLMNA | |
| SCHEMBL30739821 | 0.66 | JAK2 (0.69) | KMT2APOLBSMN1; SMN2HTTPTPN1 | |
| SCHEMBL1161155 | 0.66 | TYK2 (0.69) | KMT2ALMNAMEN1NPC1RAB9A | |
| SCHEMBL6874915 | 0.65 | NPC1 (0.69) | KMT2ASMN1; SMN2PTPN1MEN1MITF | |
| SCHEMBL10684470 | 0.65 | PTPN1 (0.88) | KMT2APOLBSMN1; SMN2HTTPTPN1 | |
| SCHEMBL7114664 | 0.65 | P2RX1 (0.55) | KMT2ASMN1; SMN2HTTPTPN1LMNA | |
| SCHEMBL7113169 | 0.65 | SNCA (0.54) | KMT2APOLBSMN1; SMN2PTPN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1038450-A | The 5-pyrimidine carboxamide analog derivative that replaces | UNIROYAL CHEM CO INC (US) | 1990-01-03 | — | — | CN | claimed |
| JP-2019317-A | — | — | None | — | — | JP | disclosed |
| CN-1014990-B | Process for the preparation of 5-pyrimidinecarboxamides derivatives | UNIROYAL CHEM CO INC (US) | 1991-12-04 | — | — | CN | disclosed |
| JP-H0219317-A | COMPOSITION FOR TREATMENT OF LEUKEMIA | UNIROYAL CHEM CO INC | 1990-01-23 | — | — | JP | disclosed |
| CN-86102767-A | The preparation method of 5-pyrimidine carboxamide analog derivative | — | 1987-01-07 | — | — | CN | disclosed |