Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122719 | 0.77 | MAPT (0.47) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL10396866 | 0.76 | MAPT (0.46) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| SCHEMBL8192297 | 0.76 | MAPT (0.46) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| SCHEMBL70023 | 0.75 | MAPT (0.48) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| Bromide SCHEMBL28730172 | 0.74 | MAPT (0.47) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| SCHEMBL5937225 | 0.72 | MAPT (0.44) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| SCHEMBL5139621 | 0.69 | MAPT (0.41) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| SCHEMBL29893540 | 0.68 | MAPT (0.52) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| SCHEMBL29098745 | 0.68 | MAPT (0.47) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA | |
| SCHEMBL3834762 | 0.67 | MAPT (0.46) | MAPTKDM4ECYP3A4SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2237925-A | — | — | None | — | — | JP | disclosed |
| JP-H02237925-A | USE OF 11-POSITION SUBSTITUTED 5,11-DIHYDRO-6HPYRIDO(23-B) (14)-BENZODIAZEPIN6-ONES IN TREATMENT OF BRADYCARDIA AND BRADYARRHYTHMIA IN HUMAN AND VETERINARY TREATMENT | DR KARL THOMAE GMBH | 1990-09-20 | — | — | JP | disclosed |