SCHEMBL10340797

SCHEMBL10340797

C[Si](C)(c1cccc(O)c1)c1cccc(O)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.54
ESR2 Q92731 1/20 0.54
ALDH1A1 P00352 5/20 0.52
CYP3A4 P08684 4/20 0.52
CA12 O43570 3/20 0.52
CA2 P00918 3/20 0.52
CA9 Q16790 3/20 0.52
CA14 Q9ULX7 2/20 0.52
LMNA P02545 1/20 0.52
CA5A P35218 1/20 0.52
HSD17B10 Q99714 1/20 0.52
CA5B Q9Y2D0 1/20 0.52
ACHE P22303 2/20 0.48
HSD17B1 P14061 5/20 0.43
HSD17B2 P37059 4/20 0.43
TSHR P16473 2/20 0.43
CA1 P00915 2/20 0.42
CYP2C9 P11712 1/20 0.42
CA7 P43166 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10950622 0.93 ESR1 (0.65) ESR1ESR2ALDH1A1CYP3A4CA12
SCHEMBL8414130 0.85 ALDH1A1 (0.52) ESR1ESR2ALDH1A1CYP3A4CA12
SCHEMBL30209191 0.85 ALDH1A1 (0.52) ESR1ESR2ALDH1A1CYP3A4CA12
SCHEMBL14163942 0.81 ALDH1A1 (0.48) ESR1ESR2ALDH1A1CYP3A4CA12
SCHEMBL30947417 0.81 ESR1 (0.50) ESR1ESR2ALDH1A1CYP3A4CA12
SCHEMBL14163941 0.79 ESR1 (0.48) ESR1ESR2ALDH1A1CYP3A4CA12
SCHEMBL10338155 0.79 ALDH1A1 (0.46) ESR1ESR2ALDH1A1CYP3A4CA12
SCHEMBL2548283 0.79 CA12 (0.58) ALDH1A1CYP3A4CA12CA2CA9
SCHEMBL79324 0.78 ALDH1A1 (0.44) ESR1ESR2ALDH1A1CYP3A4CA12
SCHEMBL9304740 0.76 ALDH1A1 (0.48) ESR1ALDH1A1CYP3A4CA12CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0220080-B1 COMPOSITIONS BASED ON PHTHALONITRILE-TERMINATED POLYARYLOXY PYRIDINE OLIGOMERS, THEIR PREPARATION, THEIR USE IN THE PREPARATION OF POLYARYLOXY PYRIDINE COPHTHALOCYANINE LATTICES AND LATTICES OBTAINED CENTRE D'ETUDE DES MATERIAUX ORGANIQUES POUR TECHNOLOGIES AVANCEES (FR) 1990-02-07 EP claimed
US-4764578-A Compositions of polyaryloxypyridine oligomers with phthalonitrile end groups, their preparation and use for manufacturing polyaryloxypyridine co-phthalocyanine lattices CENTRE D'ETUDE DES MATERIAUX ORGANIQUES POUR TECHNOLOGIES AVANCEES (FR) 1988-08-16 US claimed
US-4814403-A CROSSLINKING-HEAT, OXIDATION RESISTANCE CENTRE D'ETUDE DES MATERIAUX ORGANIQUES POUR TECHNOLOGIES AVANCEES (FR) 1989-03-21 US disclosed
US-4764578-A Compositions of polyaryloxypyridine oligomers with phthalonitrile end groups, their preparation and use for manufacturing polyaryloxypyridine co-phthalocyanine lattices CENTRE D'ETUDE DES MATERIAUX ORGANIQUES POUR TECHNOLOGIES AVANCEES (FR) 1988-08-16 US disclosed