Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 16/20 | 0.42 |
| ▸ | LOX | P28300 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10340977 | 0.95 | CA2 (0.41) | CA2LOXCA1CA4CA7 | |
| SCHEMBL10340984 | 0.79 | CA2 (0.60) | CA2LOXCA1CA4CA7 | |
| SCHEMBL10341122 | 0.78 | CA2 (0.61) | CA2LOX | |
| SCHEMBL8632622 | 0.78 | CA2 (0.49) | CA2LOX | |
| SCHEMBL10721204 | 0.77 | CA2 (0.46) | CA2LOXCA1CA4CA7 | |
| SCHEMBL23391726 | 0.77 | CA2 (0.47) | CA2LOXCA1CA4CA7 | |
| SCHEMBL10340958 | 0.76 | CA2 (0.59) | CA2LOX | |
| SCHEMBL10341129 | 0.76 | ALDH1A1 (0.49) | CA2LOXCA1CA4CA7 | |
| SCHEMBL10340905 | 0.75 | CA2 (0.58) | CA2LOXCA1CA4CA7 | |
| Hydrochloric Acid SCHEMBL10341115 | 0.75 | CA2 (0.46) | CA2LOXCA1CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221806-B1 | SUBSTITUTED THIOPHENE-2-SULFANOMIDE AND ANTIGLAUCOMA COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | claimed |
| EP-0221806-A1 | Substituted thiophene-2-sulfanomide and antiglaucoma compositions containing them | MERCK & CO. INC. (US) | 1987-05-13 | — | — | EP | claimed |
| EP-0221806-B1 | SUBSTITUTED THIOPHENE-2-SULFANOMIDE AND ANTIGLAUCOMA COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0221806-A1 | Substituted thiophene-2-sulfanomide and antiglaucoma compositions containing them | MERCK & CO. INC. (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4665090-A | TOPICAL ADMINISTRATION | MERCK & CO., INC. (US) | 1987-05-12 | — | — | US | disclosed |