Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metacresol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metacresol SCHEMBL28339537 | 1.00 | ACHE (0.81) | ACHECYP1A2CYP2C19CA12CA2 | |
| Metacresol SCHEMBL15466197 | 0.93 | ACHE (0.77) | ACHECYP1A2CYP2C19CA12CA2 | |
| Metacresol SCHEMBL6234380 | 0.93 | ACHE (0.94) | ACHECYP1A2CYP2C19CA12CA2 | |
| Metacresol SCHEMBL29352064 | 0.90 | — | — | |
| Metacresol SCHEMBL10736 | 0.90 | — | — | |
| Metacresol SCHEMBL2314567 | 0.90 | ACHE (1.00) | ACHECYP1A2CYP2C19CA12CA2 | |
| Metacresol SCHEMBL11437600 | 0.90 | ACHE (1.00) | ACHECYP1A2CYP2C19CA12CA2 | |
| Metacresol SCHEMBL9774388 | 0.90 | ACHE (1.00) | ACHECYP1A2CYP2C19CA12CA2 | |
| Metacresol SCHEMBL8883659 | 0.88 | ACHE (0.77) | ACHECYP1A2CYP2C19CA12CA2 | |
| Metacresol SCHEMBL11749131 | 0.88 | ACHE (0.85) | ACHECYP1A2CYP2C19CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115873226-B | Copolycarbonate and preparation method and application thereof | 万华化学集团股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-114349949-B | Scratch-resistant copolycarbonate and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-09-19 | — | — | CN | claimed |
| CN-114085368-B | Polycarbonate and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-08-11 | — | — | CN | claimed |
| CN-113968963-B | Polycarbonate and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-08-11 | — | — | CN | claimed |
| CN-114085368-A | Polycarbonate and preparation method and application thereof | 万华化学集团股份有限公司 | 2022-02-25 | — | — | CN | claimed |
| CN-113968963-A | Polycarbonate and preparation method and application thereof | 万华化学集团股份有限公司 | 2022-01-25 | — | — | CN | claimed |
| CN-110809594-B | Copolycarbonates and methods of making the same | 株式会社LG化学 | 2021-12-31 | — | — | CN | claimed |
| CN-110809594-A | Copolycarbonates and methods of making the same | 株式会社LG化学 | 2020-02-18 | — | — | CN | claimed |
| EP-1399498-B1 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2006-06-21 | — | — | EP | claimed |
| EP-1353971-B1 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2005-05-11 | — | — | EP | claimed |
| WO-2002055582-A2 | MELT POLYCARBONATE CATALYST SYSTEMS | GENERAL ELECTRIC COMPANY (US) | 2002-07-18 | — | — | WO | claimed |
| WO-2002055585-A2 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2002-07-18 | — | — | WO | claimed |
| WO-2002055584-A1 | MELT POLYCARBONATE CATALYST SYSTEMS | GENERAL ELECTRIC COMPANY (US) | 2002-07-18 | — | — | WO | claimed |
| WO-2002055583-A2 | MELT POLYCARBONATE CATALYST SYSTEMS | GENERAL ELECTRIC COMPANY (US) | 2002-07-18 | — | — | WO | claimed |
| US-6395862-B1 | CONTACTING DIARYLOXY COMPOUND WITH DIHYDRIC PHENOL IN THE PRESENCE OF ALKALI METAL TRIAZINE PYRIDYL SULFONATE, CARBOXY OR PHOSPHONATE | GENERAL ELECTRIC COMPANY | 2002-05-28 | — | — | US | claimed |
| US-6376640-B1 | USING CESIUM POLYMERIZATION CATALYST | GENERAL ELECTRIC COMPANY | 2002-04-23 | — | — | US | claimed |
| US-6323304-B1 | CONTACTING A DIARYLOXY COMPOUND WITH A DIHYDRIC PHENOL COMPOUND IN THE PRESENCE OF CATALYST COMPRISED OF ALKALI OR ALKALINE EARTH METAL-TRANSITION METAL FLUORIDE COMPOUND AND IN PRESENCE OF COCATALYST | GENERAL ELECTRIC COMPANY | 2001-11-27 | — | — | US | claimed |
| US-6323303-B1 | POLYMERIZING DIARYLOXY COMPOUND WITH A DIHYDRIC PHENOL COMPOUND IN THE PRESENCE OF A RUTHENIUM (II) OR RUTHENIUM (III) COMPOUND OR COMPLEX; OPTIONALLY IN PRESENCE OF A TETRAALKYL AMMONIUM OR TETRAALKYL PHOSPHONIUM SALT | GENERAL ELECTRIC COMPANY | 2001-11-27 | — | — | US | claimed |
| US-6303737-B1 | POLYCONDENSATION CATALYSTS WHICH ARE SALTS OF CERTAIN PHENANTHROLINE COMPOUNDS; EXCELLENT POLYMERIZATION RATES; REDUCING THE LEVEL OF BRANCHING SIDE REACTION, I.E., FORMATION OF FRIES PRODUCT | GENERAL ELECTRIC COMPANY | 2001-10-16 | — | — | US | claimed |
| US-6291631-B1 | CONTACTING DIARYLOXY COMPOUND WITH A DIHYDRIC PHENOL COMPOUND IN THE POLYMERIZATION CATALYST UNDER POLYCARBONATE MELT POLYMERIZATION CONDITIONS | GENERAL ELECTRIC COMPANY | 2001-09-18 | — | — | US | claimed |