Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10341192 | 0.81 | KDM4E (0.49) | KDM4EIMPDH2MEN1KMT2ACAPN1 | |
| SCHEMBL9796464 | 0.80 | BRD4 (0.42) | IMPDH2BRD4CREBBPPGRMEN1 | |
| SCHEMBL6050616 | 0.79 | KDM4E (0.56) | KDM4EMEN1KMT2AMAPTCAPN1 | |
| SCHEMBL6050602 | 0.79 | IDO1 (0.51) | KDM4ECNR2MEN1KMT2AMAPT | |
| SCHEMBL7535287 | 0.78 | IMPDH2 (0.41) | KDM1AIMPDH2BRD4CREBBPPGR | |
| SCHEMBL10341235 | 0.77 | KDM4E (0.45) | KDM4EMEN1KMT2ACAPN1CTSL | |
| SCHEMBL10341131 | 0.77 | ALDH1A1 (0.52) | KDM4ECREBBPCNR2MEN1KMT2A | |
| SCHEMBL10341044 | 0.77 | MAP2K2 (0.49) | KDM4EMEN1KMT2AMAPTCAPN1 | |
| SCHEMBL7501684 | 0.77 | IMPDH2 (0.41) | KDM1AIMPDH2BRD4CREBBPPGR | |
| SCHEMBL10341232 | 0.76 | KDM4E (0.44) | KDM4EMEN1KMT2ACAPN1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172004-B1 | QUINOLINONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | The Boots Company PLC (GB) | 1990-03-21 | — | — | EP | disclosed |
| US-4855291-A | 1,4dihydroquinoline-3-carboxamides | THE BOOTS COMPANY PLC (GB) | 1989-08-08 | — | — | US | disclosed |
| EP-0172004-A2 | Quinolinones, process for their preparation and pharmaceutical compositions containing them | The Boots Company PLC (GB) | 1986-02-19 | — | — | EP | disclosed |