Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9436035 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL9636338 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL7907379 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL13029249 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL9241350 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL7910730 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL8961773 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL7121080 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL4815333 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL2774683 | 1.00 | RARB (0.63) | RARBRAB9AKDM4ENPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0149238-B1 | NITROGEN CONTAINING HETEROCYCLES | MERCK PATENT GmbH (DE) | 1990-02-28 | — | — | EP | disclosed |
| EP-0158137-B1 | PYRIMIDINES | MERCK PATENT GmbH (DE) | 1990-01-10 | — | — | EP | disclosed |
| EP-0126949-B1 | FLUORINE-CONTAINING PYRIMIDINE DERIVATIVES | MERCK PATENT GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4713197-A | Nitrogen-containing heterocyclic compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-12-15 | — | — | US | disclosed |
| EP-0158137-A2 | Pyrimidines | MERCK PATENT GmbH (DE) | 1985-10-16 | — | — | EP | disclosed |
| EP-0149238-A2 | Nitrogen containing heterocycles | MERCK PATENT GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |
| EP-0126949-A2 | Fluorine-containing pyrimidine derivatives | MERCK PATENT GmbH (DE) | 1984-12-05 | — | — | EP | disclosed |