Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 2/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421132 | 0.94 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL421156 | 0.85 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL15868433 | 0.84 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL421095 | 0.83 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL10344908 | 0.82 | MEN1 (0.52) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL421085 | 0.82 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL464384 | 0.81 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8931147 | 0.81 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8931158 | 0.80 | ALOX5 (0.44) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL16604232 | 0.78 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013170159-A1 | TREATING CANCER WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2013-11-14 | — | — | WO | disclosed |
| WO-2013074594-A1 | COMBINATION THERAPY OF HSP90 INHIBITORS WITH BRAF INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013067162-A1 | CANCER THERAPY USING A COMBINATION OF HSP90 INHIBITORS WITH TOPOISOMERASE I INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013006864-A2 | TREATING CANCER WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2013-01-10 | — | — | WO | disclosed |
| WO-2012162584-A1 | COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH CHK INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-11-29 | — | — | WO | disclosed |
| WO-2012096919-A1 | COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH PROTEASOME INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-07-19 | — | — | WO | disclosed |
| WO-2011146803-A1 | METHOD OF TREATING LUNG ADENOCARCINOMA WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011133521-A2 | CANCER THERAPY USING A COMBINATION OF A HSP90 INHIBITORY COMPOUNDS AND A VEGF INHIBITOR | SYNTA PHARMACEUTICALS CORP. (US) | 2011-10-27 | — | — | WO | disclosed |