Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421156 | 0.92 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL464384 | 0.91 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL421132 | 0.90 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL8931242 | 0.87 | ALDH1A1 (0.47) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL10344907 | 0.84 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL421085 | 0.84 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL421407 | 0.83 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL421095 | 0.83 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL421403 | 0.80 | KDM4E (0.45) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E | |
| SCHEMBL419816 | 0.80 | MEN1 (0.53) | HSP90AA1HSP90AB1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140194388-A1 | COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH CHK INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2014-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194388-A1 | COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH CHK INHIBITORS | HSP90AB1, HSP90AA1, HSP90B1 | HSP90AA1 2/4885HSP90AB1 1/4885ALDH1A1 4166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.