Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13983090 | 0.94 | ALDH1A1 (0.41) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL12180265 | 0.83 | HSP90AA1 (0.44) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL419118 | 0.82 | ALDH1A1 (0.41) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL15042880 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL14293304 | 0.80 | HSP90AA1 (0.49) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL8931075 | 0.80 | HSP90AA1 (0.49) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL8930611 | 0.79 | HSP90AA1 (0.61) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL14344623 | 0.79 | HSP90AA1 (0.48) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL12637703 | 0.79 | HSP90AA1 (0.40) | ALDH1A1HPGDLMNAATMHSP90AA1 | |
| SCHEMBL13983147 | 0.77 | HSP90AA1 (0.43) | ALDH1A1HPGDLMNAATMHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012096919-A1 | COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH PROTEASOME INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-07-19 | — | — | WO | disclosed |
| WO-2011146801-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011133520-A1 | CANCER THERAPY USING A COMBINATION OF A HSP90 INHIBITORY COMPOUNDS AND A EGFR INHIBITOR | SYNTA PHARMACEUTICALS CORP. (US) | 2011-10-27 | — | — | WO | disclosed |