Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | HPGD | P15428 | 8/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14293132 | 0.96 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL14345419 | 0.94 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL8930858 | 0.92 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL12180064 | 0.91 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL14293304 | 0.90 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL8931075 | 0.90 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL14344623 | 0.89 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL8930870 | 0.89 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL8930766 | 0.88 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ALDH1A1HPGDPOLB | |
| SCHEMBL12045810 | 0.88 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357573-B2 | Block copolymer conjugate of physiologically active substance | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2019-07-23 | — | — | US | disclosed |
| US-20180050112-A1 | Block Copolymer Conjugate Of Physiologically Active Substance | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2018-02-22 | — | — | US | disclosed |
| US-20180050112-A1 | Block Copolymer Conjugate Of Physiologically Active Substance | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2018-02-22 | — | — | US | disclosed |
| US-20160279164-A1 | High-Molecular Weight Conjugate Of Resorcinol Derivatives | NIPPON KAYAKU KK (JP) | 2016-09-29 | — | — | US | disclosed |
| US-20160279164-A1 | High-Molecular Weight Conjugate Of Resorcinol Derivatives | NIPPON KAYAKU KK (JP) | 2016-09-29 | — | — | US | disclosed |
| WO-2016136641-A1 | BLOCK COPOLYMER CONJUGATE OF PHYSIOLOGICALLY ACTIVE SUBSTANCE | 日本化薬株式会社 | 2016-09-01 | — | — | WO | disclosed |
| EP-2298748-B1 | Triazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP (US) | 2016-07-20 | — | — | EP | disclosed |
| EP-2295416-B1 | Triazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP (US) | 2016-01-27 | — | — | EP | disclosed |
| US-9108933-B2 | Method for treating proliferative disorders associated with mutations in c-Met | SYNTA PHARMACEUTICALS CORP. (US) | 2015-08-18 | — | — | US | disclosed |
| US-9108933-B2 | Method for treating proliferative disorders associated with mutations in c-Met | SYNTA PHARMACEUTICALS CORP. (US) | 2015-08-18 | — | — | US | disclosed |
| US-20080125587-A1 | Synthesis of triazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP. | 2008-05-29 | — | — | US | disclosed |
| US-20080125587-A1 | Synthesis of triazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP. | 2008-05-29 | — | — | US | disclosed |
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20080027047-A1 | Compounds that modulate HSP90 activity and methods for identifying same | SYNTA PHARMACEUTICALS CORP | 2008-01-31 | — | — | US | disclosed |
| US-20080027047-A1 | Compounds that modulate HSP90 activity and methods for identifying same | SYNTA PHARMACEUTICALS CORP | 2008-01-31 | — | — | US | disclosed |
| US-20080004276-A1 | Method for treating non-hodgkin's lymphoma | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2008-01-03 | — | — | US | disclosed |
| US-20080004276-A1 | Method for treating non-hodgkin's lymphoma | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2008-01-03 | — | — | US | disclosed |
| US-20080004266-A1 | Method for treating proliferative disorders associated with protooncogene products | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2008-01-03 | — | — | US | disclosed |
| US-20080004266-A1 | Method for treating proliferative disorders associated with protooncogene products | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2008-01-03 | — | — | US | disclosed |
| WO-2007139960-A2 | COMPOUNDS THAT MODULATE HSP90 ACTIVITY AND METHODS FOR IDENTIFYING SAME | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125587-A1 | Synthesis of triazole compounds that modulate HSP90 activity | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSP90AB1 1/4885ALDH1A1 246/4885 |
| US-20160279164-A1 | High-Molecular Weight Conjugate Of Resorcinol Derivatives | WDR48, SLC43A1, LRAT | HSP90AA1 389/4885HSP90AB1 765/4885ALDH1A1 894/4885 |
| US-20180050112-A1 | Block Copolymer Conjugate Of Physiologically Active Substance | TACR1, PLAUR, LNPEP | HSP90AA1 1435/4885HSP90AB1 1364/4885ALDH1A1 1272/4885 |
| US-20080004276-A1 | Method for treating non-hodgkin's lymphoma | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AA1 4/4885HSP90AB1 1/4885ALDH1A1 1036/4885 |
| US-20080027047-A1 | Compounds that modulate HSP90 activity and methods for identifying same | HSP90AB1, HSP90B1, CDC37 | HSP90AA1 4/4885HSP90AB1 1/4885ALDH1A1 2231/4885 |
| US-20080004266-A1 | Method for treating proliferative disorders associated with protooncogene products | HSP90AB1, HSP90AB2P, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885ALDH1A1 1385/4885 |
| US-10357573-B2 | Block copolymer conjugate of physiologically active substance | TACR1, PLAUR, LNPEP | HSP90AA1 1435/4885HSP90AB1 1364/4885ALDH1A1 1272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.