Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.48 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10589474 | 0.84 | GCGR (0.50) | GCGRTRPV3RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14943937 | 0.77 | ALDH1A1 (0.54) | NOTUMRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL14931897 | 0.76 | PDCD1 (0.41) | TRPV3RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL20885480 | 0.74 | MEN1 (0.43) | GCGRRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL3210688 | 0.74 | MEN1 (0.43) | NOTUMRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL12427062 | 0.73 | SQOR (0.53) | RAB9AMEN1KMT2AALDH1A1PDCD1 | |
| SCHEMBL12413897 | 0.72 | GCGR (0.35) | GCGRALDH1A1CD274 | |
| SCHEMBL12427066 | 0.71 | HSD17B10 (0.50) | RAB9AMEN1KMT2AALDH1A1PDCD1 | |
| SCHEMBL10345761 | 0.71 | HPGD (0.49) | GCGRALDH1A1ADORA1ADORA2A | |
| SCHEMBL12427064 | 0.71 | SQOR (0.52) | NOTUMRAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |