Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832007 | 0.86 | MAPT (0.67) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10921971 | 0.82 | MAPT (0.65) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10922873 | 0.82 | MAPT (0.65) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL8797606 | 0.79 | ALDH1A1 (0.64) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10922029 | 0.77 | TTR (0.55) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL9218089 | 0.76 | MAPT (0.60) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10924893 | 0.76 | ALDH1A1 (0.56) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10824721 | 0.76 | MAPT (0.59) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10925162 | 0.76 | MAPT (0.58) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL655741 | 0.76 | MAPT (1.00) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4923892-A | DOXEPIN DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES | BURROUGHS WELLCOME CO. (US) | 1990-05-08 | — | — | US | disclosed |
| EP-0214779-B1 | TRICYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-04-11 | — | — | EP | disclosed |
| US-4871865-A | ANTIHISTAMINES | BURROUGHS WELLCOME CO. (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0214779-A1 | Tricyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1987-03-18 | — | — | EP | disclosed |