Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10922029 | 0.90 | TTR (0.55) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL26637991 | 0.89 | TBXAS1 (0.58) | TBXAS1TBXA2R | |
| SCHEMBL490046 | 0.88 | AKR1B1 (0.65) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL8882817 | 0.87 | AKR1B1 (0.56) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10921971 | 0.87 | MAPT (0.65) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10922873 | 0.87 | MAPT (0.65) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10345307 | 0.86 | MAPT (0.60) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10447995 | 0.85 | SRD5A2 (0.55) | ALDH1A1KDM4EGAAHPGDTBXAS1 | |
| SCHEMBL10924666 | 0.84 | TBXAS1 (0.54) | TBXAS1TBXA2R | |
| SCHEMBL8797606 | 0.83 | ALDH1A1 (0.64) | MAPTALDH1A1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0069810-B1 | NOVEL DIBENZOXEPINS, THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THE USE OF DIBENZOXEPINS IN THE TREATMENT OF ALLERGIC CONDITIONS | MERCK & CO. INC. (US) | 1986-12-03 | — | — | EP | claimed |
| EP-0069810-A1 | Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions | MERCK & CO. INC. (US) | 1983-01-19 | — | — | EP | claimed |
| EP-0798288-B1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2001-05-16 | — | — | EP | disclosed |
| EP-0549352-B1 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO KK (JP) | 2000-03-01 | — | — | EP | disclosed |
| EP-0798288-A1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-10-01 | — | — | EP | disclosed |
| US-5607955-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| US-5478840-A | Imidazo(4,5-b)pyridine derivatives used as antagonism to angiotensin ii receptors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5378701-A | Angiotensin II inhibitors; hypotensive agents; congestive heart and kidney failure; glaucoma | KYOWA HAKKO KOGYO (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0549352-A2 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |
| US-5116863-A | Antiallergens, antiinflammatory agents; asthma | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0235796-A2 | Dibenz [b,e] oxepin derivative and antiallergic and antiinflammatory agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1987-09-09 | — | — | EP | disclosed |
| EP-0069810-B1 | NOVEL DIBENZOXEPINS, THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THE USE OF DIBENZOXEPINS IN THE TREATMENT OF ALLERGIC CONDITIONS | MERCK & CO. INC. (US) | 1986-12-03 | — | — | EP | disclosed |
| EP-0069810-A1 | Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions | MERCK & CO. INC. (US) | 1983-01-19 | — | — | EP | disclosed |
| US-4282365-A | Dibenz[b,e]oxepin compounds | MERCK & CO., INC. (US) | 1981-08-04 | — | — | US | disclosed |