Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | DRD1 | P21728 | 13/20 | 0.70 |
| ▸ | DRD5 | P21918 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.70 |
| ▸ | DRD2 | P14416 | 4/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | HTR2A | P28223 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | HTR1B | P28222 | 1/20 | 0.69 |
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11406845 | 0.99 | CYP2D6 (0.80) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| Trepipam SCHEMBL11704977 | 0.90 | CYP2D6 (1.00) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| Trepipam SCHEMBL29374758 | 0.90 | CYP2D6 (1.00) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| SCHEMBL3664910 | 0.88 | DRD1 (0.71) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| SCHEMBL11939886 | 0.85 | CYP2D6 (0.81) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| SCHEMBL11112777 | 0.85 | CYP2D6 (0.81) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| SCHEMBL3666853 | 0.83 | CYP2D6 (0.57) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| SCHEMBL10749685 | 0.83 | CYP2D6 (0.78) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| SCHEMBL20415945 | 0.82 | DRD1 (1.00) | CYP2D6CYP3A4DRD1DRD5HSD17B10 | |
| SCHEMBL11398674 | 0.82 | DRD1 (1.00) | CYP2D6CYP3A4DRD1DRD5HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244088-A2 | 1-Phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders | SMITHKLINE BEECHAM CORPORATION (US) | 1987-11-04 | — | — | EP | claimed |
| EP-0230755-B1 | 1-PHENYL-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4707483-A | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0244088-A2 | 1-Phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders | SMITHKLINE BEECHAM CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| EP-0230755-A1 | 1-Phenyl-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-05 | — | — | EP | disclosed |