Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 3/20 | 0.50 |
| ▸ | ACP1 | P24666 | 2/20 | 0.50 |
| ▸ | TOP1 | P11387 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12768139 | 0.89 | ACHE (0.56) | DHODHLMNAHPGDSMN1; SMN2ACHE | |
| SCHEMBL23317018 | 0.86 | DHODH (0.51) | DHODHACP1MEN1NPC1RAB9A | |
| SCHEMBL12525154 | 0.80 | ALDH1A1 (0.61) | CYP19A1DHODHACP1TOP1MEN1 | |
| SCHEMBL8657096 | 0.79 | TOP1 (0.63) | CYP19A1DHODHACP1TOP1LMNA | |
| SCHEMBL29397116 | 0.78 | TOP1 (0.66) | CYP19A1DHODHACP1TOP1LMNA | |
| SCHEMBL28251705 | 0.78 | TOP1 (0.66) | CYP19A1DHODHACP1TOP1LMNA | |
| SCHEMBL7611160 | 0.78 | TOP1 (0.66) | CYP19A1DHODHACP1TOP1LMNA | |
| SCHEMBL6001382 | 0.76 | CYP19A1 (0.60) | CYP19A1DHODHACP1TOP1MEN1 | |
| SCHEMBL4855755 | 0.76 | CYP19A1 (0.60) | CYP19A1DHODHACP1TOP1MEN1 | |
| SCHEMBL6218255 | 0.76 | TSHR (0.54) | DHODHLMNAHPGDSMN1; SMN2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |