Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 4/20 | 0.42 |
| ▸ | MMP1 | P03956 | 3/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP7 | P09237 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345670 | 0.84 | MMP1 (0.46) | PDE4BMMP9MMP1MMP3MMP7 | |
| SCHEMBL10345640 | 0.84 | MMP1 (0.46) | PDE4BMMP9MMP1MMP3MMP7 | |
| SCHEMBL10603185 | 0.78 | GHSR (0.42) | PDE4BPTGDR2 | |
| SCHEMBL10345668 | 0.75 | DRD1 (0.57) | CYP3A4ALDH1A1 | |
| SCHEMBL10748846 | 0.72 | ESR1 (0.47) | PDE4BCYP3A4CYP2D6GRIN2CCYP2C19 | |
| SCHEMBL5471336 | 0.70 | KMT2A (0.70) | PTGDR2HCRTR1GPR183ALDH1A1 | |
| SCHEMBL8316392 | 0.68 | SMN1; SMN2 (0.61) | PDE4BMMP9MMP1MMP3MMP7 | |
| SCHEMBL3074350 | 0.68 | PDE4B (0.53) | PDE4BMMP9MMP1MMP3MMP7 | |
| SCHEMBL8316661 | 0.68 | PDE4B (0.58) | PDE4BMMP9MMP1MMP3MMP7 | |
| SCHEMBL5463056 | 0.67 | TRPV1 (0.72) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230755-B1 | 1-PHENYL-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4707483-A | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0230755-A1 | 1-Phenyl-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-05 | — | — | EP | disclosed |