Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGAV | P06756 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345901 | 1.00 | ACE (0.33) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL8600000 | 0.74 | ITGB1 (0.37) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL21424968 | 0.72 | ITGB1 (0.39) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL29954394 | 0.72 | ITGB1 (0.39) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL8866460 | 0.71 | BRD4 (0.35) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL2535132 | 0.69 | EHMT2 (0.47) | ACEITGB1ITGA5 | |
| SCHEMBL2535135 | 0.69 | EHMT2 (0.47) | ACEITGB1ITGA5 | |
| SCHEMBL18427573 | 0.67 | — | — | |
| SCHEMBL29127664 | 0.66 | SIGMAR1 (0.42) | — | |
| SCHEMBL16316835 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0171159-B1 | SUBSTITUTED AZETIDINONE COMPOUNDS, THEIR PREPARATION, AND MEDICAMENTS CONTAINING THEM | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |
| US-4719207-A | CENTRAL NERVOUS SYSTEM | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-01-12 | — | — | US | disclosed |
| EP-0171159-A1 | Substituted azetidinone compounds, their preparation, and medicaments containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-02-12 | — | — | EP | disclosed |