Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 4/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 4/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGAV | P06756 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866460 | 0.83 | BRD4 (0.35) | ITGB1ITGA5ACEITGB3ITGAV | |
| SCHEMBL29954394 | 0.81 | ITGB1 (0.39) | ITGB1ITGA5ACEITGB3ITGAV | |
| SCHEMBL21424968 | 0.81 | ITGB1 (0.39) | ITGB1ITGA5ACEITGB3ITGAV | |
| SCHEMBL7403414 | 0.76 | ITGB1 (0.33) | ITGB1ITGA5ACEITGB3ITGAV | |
| SCHEMBL2535132 | 0.74 | EHMT2 (0.47) | ITGB1ITGA5ACEGAA | |
| SCHEMBL10345901 | 0.74 | ACE (0.33) | ITGB1ITGA5ACEITGB3ITGAV | |
| SCHEMBL10345950 | 0.74 | ACE (0.33) | ITGB1ITGA5ACEITGB3ITGAV | |
| SCHEMBL2535135 | 0.74 | EHMT2 (0.47) | ITGB1ITGA5ACEGAA | |
| SCHEMBL7406627 | 0.73 | ITGB1 (0.41) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL29127664 | 0.70 | SIGMAR1 (0.42) | SIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998612-A | Antibiotic synthesis | MERCK SHARP & DOHME CORP. | 1999-12-07 | — | — | US | disclosed |
| EP-0171159-B1 | SUBSTITUTED AZETIDINONE COMPOUNDS, THEIR PREPARATION, AND MEDICAMENTS CONTAINING THEM | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |
| EP-0078026-B1 | ANTIBIOTIC SYNTHESIS | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| US-4719207-A | CENTRAL NERVOUS SYSTEM | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-01-12 | — | — | US | disclosed |
| EP-0171159-A1 | Substituted azetidinone compounds, their preparation, and medicaments containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-02-12 | — | — | EP | disclosed |
| EP-0078026-A2 | Antibiotic synthesis | MERCK & CO. INC. (US) | 1983-05-04 | — | — | EP | disclosed |