Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032619 | 0.96 | THRA (0.39) | NPC1RAB9AMTNR1ASMN1; SMN2EGLN1 | |
| SCHEMBL1033120 | 0.91 | SMN1; SMN2 (0.47) | NPC1RAB9AMTNR1ASMN1; SMN2EGLN1 | |
| SCHEMBL1031021 | 0.89 | NPC1 (0.38) | NPC1RAB9AMTNR1ASMN1; SMN2EGLN1 | |
| SCHEMBL1033428 | 0.88 | NPC1 (0.37) | NPC1RAB9AMTNR1ASMN1; SMN2EGLN1 | |
| SCHEMBL1030683 | 0.86 | SMN1; SMN2 (0.47) | NPC1RAB9AMTNR1ASMN1; SMN2EGLN1 | |
| SCHEMBL1033585 | 0.84 | THRA (0.41) | NPC1RAB9AMTNR1ASMN1; SMN2EGLN1 | |
| SCHEMBL1032319 | 0.84 | THRA (0.38) | NPC1RAB9AMTNR1ASMN1; SMN2EGLN1 | |
| SCHEMBL522146 | 0.83 | EGLN1 (0.50) | EGLN1THRATHRB | |
| SCHEMBL1033757 | 0.82 | SCN9A (0.35) | NPC1RAB9AMTNR1AEGLN1THRA | |
| SCHEMBL1033539 | 0.81 | EGLN1 (0.46) | EGLN1THRATHRBPDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-B1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN INC (US) | 2011-01-19 | — | — | EP | claimed |