Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 5/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.46 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033035 | 0.88 | EGLN1 (0.47) | EGLN1BBOX1FTOTHRATHRB | |
| SCHEMBL1028658 | 0.87 | EGLN1 (0.46) | EGLN1BBOX1FTOCYP1A2TSHR | |
| SCHEMBL1028622 | 0.85 | EGLN1 (0.47) | EGLN1BBOX1FTOTSHR | |
| SCHEMBL1032271 | 0.84 | FTO (0.43) | EGLN1BBOX1FTO | |
| SCHEMBL1032619 | 0.81 | THRA (0.39) | EGLN1BBOX1FTOPDCD1LG2CD274 | |
| SCHEMBL1034732 | 0.81 | NPC1 (0.38) | EGLN1PDCD1LG2CD274THRATHRB | |
| SCHEMBL522140 | 0.77 | EGLN1 (0.71) | EGLN1BBOX1FTOTHRATHRB | |
| SCHEMBL1033387 | 0.77 | FTO (0.46) | EGLN1BBOX1FTOTHRATHRB | |
| SCHEMBL4073465 | 0.76 | EGLN1 (0.49) | EGLN1BBOX1FTOTHRATHRB | |
| SCHEMBL4081511 | 0.75 | EGLN1 (0.49) | EGLN1BBOX1FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-B1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN INC (US) | 2011-01-19 | — | — | EP | claimed |