Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.76 |
| ▸ | CA1 | P00915 | 8/20 | 0.76 |
| ▸ | CA4 | P22748 | 5/20 | 0.76 |
| ▸ | CA12 | O43570 | 3/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.62 |
| ▸ | CA7 | P43166 | 2/20 | 0.62 |
| ▸ | CA5A | P35218 | 3/20 | 0.55 |
| ▸ | CA6 | P23280 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9459715 | 0.86 | CA2 (1.00) | CA2CA1CA4CA12CA14 | |
| SCHEMBL14317794 | 0.81 | CA2 (0.67) | CA2CA1CA4CA12CA14 | |
| SCHEMBL564235 | 0.81 | CA2 (1.00) | CA2CA1CA4CA12CA14 | |
| SCHEMBL31452866 | 0.81 | CA2 (0.67) | CA2CA1CA4CA12CA14 | |
| SCHEMBL14299650 | 0.78 | CA2 (0.61) | CA2CA1CA4CA12CA14 | |
| SCHEMBL10913170 | 0.78 | CA2 (0.64) | CA2CA1CA4CA12CA14 | |
| SCHEMBL81178 | 0.77 | CA2 (1.00) | CA2CA1CA4CA12CA14 | |
| SCHEMBL30297744 | 0.77 | CA2 (1.00) | CA2CA1CA4CA12CA14 | |
| SCHEMBL10924391 | 0.76 | CA2 (0.88) | CA2CA1CA4CA12CA14 | |
| Fluoride SCHEMBL27730918 | 0.75 | CA2 (0.96) | CA2CA1CA4CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122831-B1 | BENZOTHIAZOLE-2-SULFONAMIDE DERIVATIVES FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1990-04-18 | — | — | EP | disclosed |
| US-4499103-A | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure | MERCK & CO., INC. (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0122831-A2 | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1984-10-24 | — | — | EP | disclosed |