SCHEMBL81178

SCHEMBL81178

NS(=O)(=O)c1nc2ccccc2s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 13/20 1.00
CA1 P00915 7/20 1.00
CA12 O43570 5/20 1.00
CA4 P22748 4/20 1.00
CA7 P43166 4/20 1.00
CA14 Q9ULX7 3/20 1.00
PSMB8 P28062 1/20 0.70
PSMB5 P28074 1/20 0.70
CA5A P35218 3/20 0.60
CA9 Q16790 3/20 0.60
CA6 P23280 2/20 0.60
CA5B Q9Y2D0 2/20 0.60
LMNA P02545 3/20 0.57
KMT2A Q03164 3/20 0.57
ALDH1A1 P00352 2/20 0.57
MAPT P10636 2/20 0.57
HTT P42858 2/20 0.57
MEN1 O00255 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
CA13 Q8N1Q1 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30297744 1.00 CA2 (1.00) CA2CA1CA12CA4CA7
SCHEMBL464742 0.85 CA2 (0.72) CA2CA1CA12CA4CA7
SCHEMBL2711265 0.84 PSMB8 (0.75) CA2CA1CA12CA4CA7
Morpholine SCHEMBL9354773 0.84 CA2 (0.70) CA2CA1CA12CA4CA7
SCHEMBL29164335 0.82 PSMB8 (1.00) CA2CA1CA12CA4CA7
SCHEMBL30817868 0.82 PSMB8 (1.00) CA2CA1CA12CA4CA7
SCHEMBL329577 0.82 PSMB8 (0.72) CA2CA1CA12CA4CA7
SCHEMBL23626381 0.81 PSMB8 (0.70) CA2CA1CA12CA4CA7
SCHEMBL13851203 0.81 PSMB8 (0.70) CA2CA1CA12CA4CA7
SCHEMBL10336550 0.81 PSMB8 (0.70) CA2CA1CA12CA4CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 621 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025118348-A1 GRAPHENE-MODIFIED NATURAL RUBBER THAT IS SIMULTANEOUSLY REINFORCED AND TOUGHENED BASED ON STRONG INTERFACE ACTION OF FREE RADICAL ANNIHILATION REACTION 中北大学 2025-06-12 WO claimed
US-12296230-B2 Biodegradable sports ball and method for manufacture thereof HEAD TECHNOLOGY GMBH (AT) 2025-05-13 US claimed
WO-2024263109-A1 TRAINING MODEL FOR VESSEL PUNCTURE AND CATHETERIZATION MAHIDOL UNIVERSITY (TH) 2024-12-26 WO claimed
CN-118388852-B Wear-resistant stretch-resistant cable and preparation method thereof 广东万瑞通电缆实业有限公司 2024-08-20 CN claimed
CN-118388852-A Wear-resistant stretch-resistant cable and preparation method thereof 广东万瑞通电缆实业有限公司 2024-07-26 CN claimed
US-20240216762-A1 BIODEGRADABLE SPORTS BALL AND METHOD FOR MANUFACTURE THEREOF HEAD TECHNOLOGY GMBH (AT) 2024-07-04 US claimed
US-20240208128-A1 SYSTEM AND METHOD FOR CONTINUOUSLY MANUFACTURING CURED MEMBRANES AMRIZE TECHNOLOGY SWITZERLAND LLC (CH) 2024-06-27 US claimed
EP-4330000-A1 SYSTEM AND METHOD FOR CONTINUOUSLY MANUFACTURING CURED MEMBRANES Holcim Technology Ltd (CH) 2024-03-06 EP claimed
US-11725097-B2 Elastomeric article TOP GLOVE INTERNATIONAL SDN. BHD. 2023-08-15 US claimed
CN-114213721-B Rubber composition and preparation method thereof 青岛双星轮胎工业有限公司 2023-04-07 CN claimed
EP-0419311-A2 Prodrugs of carbonic anhydrase inhibitors UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1991-03-27 EP claimed
US-4975449-A EYE DROP FOR REDUCING INTRAOCULAR EYE PRESSURE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1990-12-04 US claimed
EP-0122831-B1 BENZOTHIAZOLE-2-SULFONAMIDE DERIVATIVES FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURE MERCK & CO. INC. (US) 1990-04-18 EP claimed
EP-0154437-B1 SUBSTITUTED DITHIOCARBAMYLUREA ACCELERATORS UNIROYAL CHEMICAL COMPANY, Inc. (US) 1989-06-14 EP claimed
US-4822838-A BLENDED WITH EPICHLORHYDRIN POLYMER OR POLYMERS OSAKA SODA CO., LTD. (JP) 1989-04-18 US claimed
EP-0079269-B1 HYDROXY-SUBSTITUTED-2-BENZOTHIAZOLESULFONAMIDE FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURE MERCK & CO. INC. (US) 1986-05-14 EP claimed
EP-0070239-B1 BENZOTHIAZOLESULFONAMIDE DERIVATIVES, THEIR PREPARATION AND OPHTHALMIC COMPOSITIONS CONTAINING SAID DERIVATIVES MERCK & CO. INC. (US) 1985-06-05 EP claimed
EP-0122831-A2 Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure MERCK & CO. INC. (US) 1984-10-24 EP claimed
EP-0070239-A1 Benzothiazolesulfonamide derivatives, their preparation and ophthalmic compositions containing said derivatives MERCK & CO. INC. (US) 1983-01-19 EP claimed
US-4216207-A Method and composition for treatment of gastro-duodenal ulcers CENTRALA INDUSTRIALA DE MEDICAMENTE COSMETICE COLORANTI SI LACURI (RO) 1980-08-05 US claimed