SCHEMBL10348129

SCHEMBL10348129

FC(F)(F)c1ccc(-n2cccn2)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
MEN1 O00255 2/20 0.42
MAPT P10636 2/20 0.42
KMT2A Q03164 2/20 0.42
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42
GAA P10253 1/20 0.42
G6PD P11413 1/20 0.42
PKM P14618 1/20 0.41
NOTUM Q6P988 3/20 0.41
MALT1 Q9UDY8 1/20 0.41
IDH2 P48735 1/20 0.40
NTRK1 P04629 3/20 0.38
NPC1 O15118 1/20 0.38
MAPK1 P28482 1/20 0.38
GPR119 Q8TDV5 1/20 0.38
PDE2A O00408 1/20 0.37
HCRTR1 O43613 3/20 0.37
PDE9A O76083 1/20 0.37
HCRTR2 O43614 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12750055 0.83 ALDH1A1 (0.43) ALDH1A1MEN1MAPTKMT2AKDM4E
SCHEMBL10104439 0.83 ALDH1A1 (0.43) ALDH1A1MEN1MAPTKMT2AKDM4E
SCHEMBL996130 0.81 ALDH1A1 (0.61) ALDH1A1MEN1MAPTKMT2AKDM4E
SCHEMBL18608785 0.81 ALDH1A1 (0.42) ALDH1A1MEN1MAPTKMT2AKDM4E
SCHEMBL2078575 0.79 GABRB3 (0.49)
SCHEMBL27819827 0.79 KCNN4 (0.50) ALDH1A1MEN1MAPTKMT2AKDM4E
SCHEMBL30055522 0.78 NOTUM (0.56) ALDH1A1MEN1MAPTKMT2AKDM4E
SCHEMBL11023550 0.78 NOTUM (0.56) ALDH1A1MEN1MAPTKMT2AKDM4E
SCHEMBL20336332 0.78 ALDH1A1 (0.49) ALDH1A1MEN1MAPTKMT2AKDM4E
SCHEMBL17141721 0.78 MEN1 (0.59) ALDH1A1MEN1MAPTKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0200872-B1 HERBICIDAL AND INSECTICIDAL AGENT BASED ON PYRAZOL DERIVATIVES BAYER AG (DE) 1990-04-18 EP disclosed
US-4746354-A PRE- AND POSTEMERGENCE BAYER AKTIENGESELLSCHAFT (DE) 1988-05-24 US disclosed
EP-0200872-A1 Herbicidal and insecticidal agent based on pyrazol derivatives BAYER AG (DE) 1986-11-12 EP disclosed