SCHEMBL10348307

SCHEMBL10348307

O=C(F)c1cccc(SC(F)(F)F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.50
MAPT P10636 1/20 0.50
TSHR P16473 1/20 0.50
MAPK1 P28482 1/20 0.50
HTT P42858 1/20 0.50
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
HPGD P15428 1/20 0.44
HSD17B10 Q99714 1/20 0.44
PDE5A O76074 1/20 0.43
PDE1A P54750 1/20 0.43
PDE1B Q01064 1/20 0.43
PDE1C Q14123 1/20 0.43
TRPV1 Q8NER1 5/20 0.40
BRAF P15056 2/20 0.40
CES2 O00748 1/20 0.39
APEX1 P27695 1/20 0.39
KCNK2 O95069 2/20 0.38
KCNK10 P57789 1/20 0.38
RXFP1 Q9HBX9 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26622156 0.85 LMNA (0.54) LMNAMAPTTSHRMAPK1HTT
SCHEMBL879988 0.85 CYP1A2 (0.63) LMNAMAPTTSHRMAPK1HTT
SCHEMBL29508729 0.85 CYP1A2 (0.63) LMNAMAPTTSHRMAPK1HTT
SCHEMBL1448525 0.84 TSHR (0.49) LMNAMAPTTSHRMAPK1HTT
SCHEMBL2787937 0.84 TSHR (0.53) LMNAMAPTTSHRMAPK1HTT
SCHEMBL513796 0.84 LMNA (0.49) LMNAMAPTTSHRMAPK1HTT
SCHEMBL842358 0.84 MAPK1 (0.49) LMNAMAPTTSHRMAPK1HTT
SCHEMBL28327989 0.82 MAPT (0.63) LMNAMAPTTSHRMAPK1HTT
SCHEMBL2644958 0.81 MAPK1 (0.50) LMNAMAPTTSHRMAPK1HTT
SCHEMBL2378105 0.80 MAPK1 (0.47) LMNAMAPTTSHRMAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0120352-B1 DERIVATIVES OF N-ACYLANTHRANILIC ACIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN COMBATING WEEDS BASF Aktiengesellschaft (DE) 1990-06-13 EP disclosed
EP-0170203-A2 4H-Pyrido(2,3-d)(1,3)oxazin-4-one derivatives, process for their preparation, and their use for combating undesired vegetation BASF Aktiengesellschaft (DE) 1986-02-05 EP disclosed
EP-0120352-A1 Derivatives of N-acylanthranilic acids, process for their preparation and their use in combating weeds BASF Aktiengesellschaft (DE) 1984-10-03 EP disclosed