SCHEMBL879988

SCHEMBL879988

O=C(O)c1cccc(SC(F)(F)F)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.63
CYP2C9 P11712 1/20 0.63
HPGD P15428 1/20 0.63
HSD17B10 Q99714 1/20 0.63
APEX1 P27695 1/20 0.54
LMNA P02545 1/20 0.54
MAPT P10636 1/20 0.54
TSHR P16473 1/20 0.54
MAPK1 P28482 1/20 0.54
HTT P42858 1/20 0.54
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA6 P23280 1/20 0.47
CA9 Q16790 1/20 0.47
KCNK2 O95069 2/20 0.44
KCNK10 P57789 1/20 0.44
KMO O15229 1/20 0.44
AKR1C3 P42330 2/20 0.44
AKR1C2 P52895 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29508729 1.00 CYP1A2 (0.63) CYP1A2CYP2C9HPGDHSD17B10APEX1
SCHEMBL28327989 0.86 MAPT (0.63) CYP1A2CYP2C9HPGDHSD17B10LMNA
SCHEMBL3553668 0.86 CYP1A2 (0.59) CYP1A2CYP2C9HPGDHSD17B10APEX1
SCHEMBL10348307 0.85 LMNA (0.50) CYP1A2CYP2C9HPGDHSD17B10APEX1
SCHEMBL26622156 0.85 LMNA (0.54) CYP1A2CYP2C9HPGDHSD17B10APEX1
SCHEMBL2787937 0.84 TSHR (0.53) CYP1A2CYP2C9HPGDHSD17B10LMNA
SCHEMBL513796 0.84 LMNA (0.49) CYP1A2CYP2C9HPGDHSD17B10APEX1
SCHEMBL1448525 0.84 TSHR (0.49) CYP1A2CYP2C9HPGDHSD17B10APEX1
SCHEMBL842358 0.84 MAPK1 (0.49) CYP1A2CYP2C9HPGDHSD17B10LMNA
SCHEMBL5315806 0.81 HSD17B10 (0.63) CYP1A2CYP2C9HPGDHSD17B10APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 US disclosed
US-12577244-B2 Heterocyclic compound and harmful arthropod-controlling composition containing same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2026-03-17 US disclosed
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2025-10-09 US disclosed
EP-4536653-A2 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME Eisai R&D Management Co., Ltd. (JP) 2025-04-16 EP disclosed
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO, INC. 2024-12-12 US disclosed
CN-118791407-A Sulfinylamino group benzamide and process for preparing same Sulfonylamino benzamide derivatives 奥索生物公司 2024-10-18 CN disclosed
CN-118638096-A Sulfinylamino group benzamide and process for preparing same Sulfonylamino benzamide derivatives 奥索生物公司 2024-09-13 CN disclosed
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2024-07-30 US disclosed
CN-112204008-B Sulfonylaminobenzamides and sulfonylaminobenzamide derivatives 奥索生物公司 2024-07-05 CN disclosed
US-20240010648-A1 HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD-CONTROLLING COMPOSITION CONTAINING SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-01-11 US disclosed
CN-1391565-A Benzophenones as reverse transcriptase inhibitors GLAXO GROUP LTD (GB) 2003-01-15 CN disclosed
US-20020127577-A1 Bioactive sensors GRAFFINITY PHARMACEUTICALS AG (DE) 2002-09-12 US disclosed
EP-1238970-A1 CYCLOAMINE CCR5 RECEPTOR ANTAGONISTS TEIJIN LIMITED (JP) 2002-09-11 EP disclosed
WO-2002063299-A1 LOW AFFINITY SCREENING METHOD GRAFFINITY PHARMACEUTICALS AG (DE) 2002-08-15 WO disclosed
WO-2002050019-A2 DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB PHARMA CO. (US) 2002-06-27 WO disclosed
EP-1208091-A1 BENZOPHENONES AS INHIBITORS OF REVERSE TRANSCRIPTASE GLAXO GROUP LIMITED (GB) 2002-05-29 EP disclosed
EP-1185869-A2 LIGAND-ANCHOR CONJUGATES FOR PRODUCING A BIOSENSOR LAYER Graffinity Pharmaceutical Design GmbH (DE) 2002-03-13 EP disclosed
WO-2001017982-A1 BENZOPHENONES AS INHIBITORS OF REVERSE TRANSCRIPTASE GLAXO GROUP LIMITED (GB) 2001-03-15 WO disclosed
WO-2000073796-A2 LIGAND-ANCHOR CONJUGATES FOR PRODUCING A BIOSENSOR LAYER GRAFFINITY PHARMACEUTICAL DESIGN GMBH (DE) 2000-12-07 WO disclosed
US-4020169-A FROM ARYL IODIDE OR BROMIDE AND TRIFLUOROMETHYL THIO COPPER MERCK & CO., INC. (US) 1977-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577244-B2 Heterocyclic compound and harmful arthropod-controlling composition containing same CYC1, COX6C, CBR3 CYP1A2 251/4885CYP2C9 371/4885HPGD 3189/4885
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B CYP1A2 549/4885CYP2C9 443/4885HPGD 2345/4885
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME NEU1, NEU2, NEU4 CYP1A2 2169/4885CYP2C9 2725/4885HPGD 1182/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 CYP1A2 585/4885CYP2C9 418/4885HPGD 2085/4885
US-20240010648-A1 HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD-CONTROLLING COMPOSITION CONTAINING SAME C3AR1, C5, NR4A3 CYP1A2 126/4885CYP2C9 354/4885HPGD 2853/4885
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B CYP1A2 549/4885CYP2C9 443/4885HPGD 2345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.