SCHEMBL10348690

SCHEMBL10348690

CC(CO)(CO)NCc1c2ccccc2cc2cc3ccccc3cc12.CS(=O)(=O)O

nearest known ligand 0.48

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A known ✓ P28223 1/20 0.34
TUBB4A known ✓ P04350 1/20 0.33
TUBB known ✓ P07437 1/20 0.33
TUBA3C known ✓ P0DPH7 1/20 0.33
TUBA1B known ✓ P68363 1/20 0.33
TUBA4A known ✓ P68366 1/20 0.33
TUBB4B known ✓ P68371 1/20 0.33
TUBB3 known ✓ Q13509 1/20 0.33
TUBB2A known ✓ Q13885 1/20 0.33
TUBB8 known ✓ Q3ZCM7 1/20 0.33
TUBA3E known ✓ Q6PEY2 1/20 0.33
TUBA1A known ✓ Q71U36 1/20 0.33
TUBA1C known ✓ Q9BQE3 1/20 0.33
TUBB6 known ✓ Q9BUF5 1/20 0.33
TUBB2B known ✓ Q9BVA1 1/20 0.33
TUBB1 known ✓ Q9H4B7 1/20 0.33
SLC2A1 P11166 6/20 0.48
NPBWR1 P48145 1/20 0.37
KMT2A Q03164 1/20 0.37
MCHR1 Q99705 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10348808 0.93 KMT2A (0.40) SLC2A1NPBWR1KMT2AMCHR1POLB
SCHEMBL10348691 0.88 SLC2A1 (0.39) SLC2A1NPBWR1KMT2AMCHR1POLB
SCHEMBL10488406 0.88 HTR2A (0.43) SLC2A1NPBWR1KMT2AMCHR1POLB
SCHEMBL10484379 0.88 SLC2A1 (0.49) SLC2A1NPBWR1KMT2AMCHR1L3MBTL1
SCHEMBL10488324 0.87 SLC2A1 (0.46) SLC2A1NPBWR1KMT2AMCHR1POLB
SCHEMBL10488232 0.87 SLC2A1 (0.46) SLC2A1NPBWR1KMT2AMCHR1POLB
Hydrochloric Acid SCHEMBL10488372 0.86 KMT2A (0.43) SLC2A1NPBWR1KMT2AMCHR1POLB
SCHEMBL10488350 0.85 SLC2A1 (0.45) SLC2A1NPBWR1KMT2AMCHR1CD274
SCHEMBL10349036 0.84 SLC2A1 (0.46) SLC2A1NPBWR1KMT2AMCHR1CD274
SCHEMBL9537779 0.83 SLC2A1 (0.51) SLC2A1NPBWR1KMT2AMCHR1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0182609-B1 POLYCYCLIC BIOCIDAL COMPOUNDS, THEIR SYNTHESIS, FORMULATIONS CONTAINING THEM THE WELLCOME FOUNDATION LIMITED (GB) 1990-05-09 EP disclosed
US-4882358-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-11-21 US disclosed
US-4827034-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1989-05-02 US disclosed
US-4818443-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-04-04 US disclosed
US-4814502-A ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS BURROUGHS WELLCOME CO. (US) 1989-03-21 US disclosed
US-4810823-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-03-07 US disclosed
US-4808753-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-02-28 US disclosed
US-4791233-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1988-12-13 US disclosed
US-4791232-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1988-12-13 US disclosed
US-4791231-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1988-12-13 US disclosed
EP-0182609-A2 Polycyclic biocidal compounds, their synthesis, formulations containing them THE WELLCOME FOUNDATION LIMITED (GB) 1986-05-28 EP disclosed