Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28179466 | 0.87 | TSHR (0.43) | TSHRSMN1; SMN2OPRM1 | |
| SCHEMBL2213674 | 0.86 | TSHR (0.45) | TSHRSMN1; SMN2LMNAOPRM1CETP | |
| SCHEMBL5817634 | 0.85 | TSHR (0.41) | TSHRSMN1; SMN2LMNAOPRM1 | |
| SCHEMBL28950012 | 0.83 | DNM1 (0.44) | TSHRSMN1; SMN2LMNAOPRM1 | |
| SCHEMBL14958105 | 0.83 | TSHR (0.38) | TSHRSMN1; SMN2LMNAOPRM1 | |
| SCHEMBL9416100 | 0.83 | DNM1 (0.44) | TSHRSMN1; SMN2LMNAOPRM1 | |
| SCHEMBL15544535 | 0.83 | DNM1 (0.44) | TSHRSMN1; SMN2LMNAOPRM1 | |
| SCHEMBL11804936 | 0.82 | TSHR (0.41) | TSHRSMN1; SMN2LMNAOPRM1CNR1 | |
| SCHEMBL28100004 | 0.81 | LMNA (0.38) | TSHRSMN1; SMN2LMNAOPRM1 | |
| SCHEMBL2076547 | 0.81 | TSHR (0.44) | TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0218433-B1 | SELECTIVE METHOD FOR BLOCKING 5HT2 RECEPTORS | ELI LILLY AND COMPANY (US) | 1990-06-20 | — | — | EP | disclosed |
| US-4810710-A | SEROTONIN BLOCKERS | ELI LILLY AND COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| US-4762842-A | SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY (US) | 1988-08-09 | — | — | US | disclosed |
| US-4713384-A | HYPOTENSIVE AND ANTIMIGRAINE AGENTS | ELI LILLY AND COMPANY (US) | 1987-12-15 | — | — | US | disclosed |
| EP-0218433-A1 | Selective method for blocking 5HT2 receptors | ELI LILLY AND COMPANY (US) | 1987-04-15 | — | — | EP | disclosed |