Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10969690 | 0.84 | USP2 (0.56) | HTTUSP2KDM4EALDH1A1ALOX15 | |
| SCHEMBL10969687 | 0.84 | USP2 (0.56) | HTTUSP2KDM4EALDH1A1ALOX15 | |
| Iodide SCHEMBL10378669 | 0.84 | USP2 (0.49) | HTTUSP2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11154509 | 0.84 | HTT (0.50) | HTTUSP2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8253252 | 0.79 | USP2 (0.45) | HTTUSP2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL13924017 | 0.78 | KDM4E (0.55) | HTTUSP2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19257794 | 0.77 | USP2 (0.74) | HTTUSP2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11154511 | 0.77 | KDM4E (0.58) | HTTUSP2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL21581245 | 0.77 | GNAI3 (0.50) | USP2KDM4EGNAI3GNAO1GNAI1 | |
| SCHEMBL10511992 | 0.76 | USP2 (0.71) | HTTUSP2CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269383-A3 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-05-02 | — | — | EP | disclosed |
| EP-0269383-A3 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-05-02 | — | — | EP | disclosed |
| US-4882330-A | 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-11-21 | — | — | US | disclosed |
| US-4882330-A | 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0269383-A2 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | disclosed |
| EP-0269383-A2 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | disclosed |
| EP-0269383-A2 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | disclosed |