Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10549794 | 1.00 | NPSR1 (0.46) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL1769201 | 0.83 | NPSR1 (0.50) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL3900070 | 0.80 | AKR1C1 (0.59) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL3224174 | 0.80 | NPSR1 (0.55) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL10548355 | 0.76 | CES1 (0.44) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL3904809 | 0.76 | L3MBTL1 (0.64) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL10350123 | 0.76 | CES1 (0.44) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL3909752 | 0.75 | ALDH1A1 (0.55) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL6607473 | 0.75 | NPSR1 (0.52) | NPSR1MAPTHTR1ES1PR3MEN1 | |
| SCHEMBL31488838 | 0.73 | NPC1 (0.50) | NPSR1MAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4857660-A | ENZYME INHIBITORS, ANTICANCER AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-08-15 | — | — | US | claimed |
| EP-0166692-B1 | SUBSTITUTED AZABICYCLOHEPTANES, THEIR USE, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESS FOR THE PREPARATION OF THE COMPOUNDS | CIBA-GEIGY AG (CH) | 1990-07-11 | — | — | EP | disclosed |
| US-4857660-A | ENZYME INHIBITORS, ANTICANCER AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-08-15 | — | — | US | disclosed |
| US-4764640-A | AROMATOSE INHIBITOR | CIBA-GEIGY CORPORATION (US) | 1988-08-16 | — | — | US | disclosed |
| US-4677129-A | Substituted-3-azabicyclo[3.1.1]heptane-2,4-diones useful for treating hormone-dependent diseases | CIBA-GEIGY CORPORATION (US) | 1987-06-30 | — | — | US | disclosed |
| EP-0166692-A2 | Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds | CIBA-GEIGY AG (CH) | 1986-01-02 | — | — | EP | disclosed |