Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | TNKS | O95271 | 15/20 | 0.64 |
| ▸ | TNKS2 | Q9H2K2 | 15/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.56 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.56 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342910 | 0.87 | HPGD (1.00) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL1031367 | 0.83 | ALDH1A1 (1.00) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL1081986 | 0.83 | HPGD (0.75) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL15173439 | 0.80 | HPGD (0.69) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL15173139 | 0.79 | HPGD (0.56) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL15173047 | 0.79 | HPGD (0.68) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL20955312 | 0.79 | HPGD (0.68) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL15173184 | 0.77 | POLB (0.72) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL15188523 | 0.77 | HPGD (0.66) | HPGDALDH1A1TSHRPOLBTNKS | |
| SCHEMBL15173387 | 0.77 | HPGD (0.74) | HPGDALDH1A1TSHRPOLBTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9339503-B2 | Tetrahydro-quinazolinone derivatives as TANK and PARP inhibitors | MERCK PATENT GMBH (DE) | 2016-05-17 | — | — | US | claimed |
| US-20150025071-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | claimed |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | FINSINGER DIRK | 2011-08-11 | — | — | US | claimed |
| EP-1856061-B1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2011-01-26 | — | — | EP | claimed |
| EP-1856061-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | Merck Patent GmbH (DE) | 2007-11-21 | — | — | EP | claimed |
| WO-2006094604-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | claimed |
| US-8268845-B2 | Tetrahydro- and dihydroquinazolinones | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | FINSINGER DIRK | 2011-08-11 | — | — | US | disclosed |
| EP-1856061-B1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2011-01-26 | — | — | EP | disclosed |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
| EP-1856061-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | Merck Patent GmbH (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094604-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025071-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | TNKS, PARP1, PARP11 | HPGD 533/4885ALDH1A1 1134/4885TSHR 4086/4885 |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, CSNK1E | HPGD 217/4885ALDH1A1 1936/4885TSHR 4253/4885 |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, DMPK | HPGD 259/4885ALDH1A1 2043/4885TSHR 4328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.