Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | TNKS | O95271 | 11/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 11/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.60 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.60 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.58 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.58 |
| ▸ | SPR | P35270 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342910 | 0.86 | HPGD (1.00) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL15173439 | 0.84 | HPGD (0.69) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL1035103 | 0.83 | HPGD (0.77) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL15173047 | 0.83 | HPGD (0.68) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL15173184 | 0.82 | POLB (0.72) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL1031367 | 0.82 | ALDH1A1 (1.00) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL15173196 | 0.80 | HPGD (0.63) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL18058753 | 0.79 | TNKS (0.65) | TNKSTNKS2PARP1 | |
| SCHEMBL15173387 | 0.79 | HPGD (0.74) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL15173320 | 0.78 | TNKS (0.77) | HPGDPOLBALDH1A1TSHRTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268845-B2 | Tetrahydro- and dihydroquinazolinones | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | FINSINGER DIRK | 2011-08-11 | — | — | US | disclosed |
| EP-1856061-B1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2011-01-26 | — | — | EP | disclosed |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, CSNK1E | HPGD 217/4885POLB 2269/4885ALDH1A1 1936/4885 |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, DMPK | HPGD 259/4885POLB 2214/4885ALDH1A1 2043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.