Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.52 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.52 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.52 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10351747 | 0.90 | KMT2A (0.52) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL301027 | 0.87 | KMT2A (0.64) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL503291 | 0.81 | KMT2A (0.65) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL3443266 | 0.81 | KMT2A (0.61) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL21874196 | 0.80 | KMT2A (0.57) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL10351842 | 0.80 | OPRM1 (0.53) | — | |
| SCHEMBL503877 | 0.79 | KMT2A (0.63) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL21874269 | 0.79 | KMT2A (0.63) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL16058193 | 0.77 | KMT2A (0.57) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL11096445 | 0.77 | KMT2A (0.57) | KMT2ATET3FBXL19CXXC5TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8669246-B2 | Substituted amide compound | ASTELLAS PHARMA INC. (JP) | 2014-03-11 | — | — | US | disclosed |
| US-20130231320-A1 | SUBSTITUTED AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-09-05 | — | — | US | disclosed |
| US-20120184521-A1 | SUBSTITUTED AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184521-A1 | SUBSTITUTED AMIDE COMPOUND | LPAR1, LPAR2, LPAR3 | KMT2A 586/4885TET3 4856/4885FBXL19 946/4885 |
| US-20130231320-A1 | SUBSTITUTED AMIDE COMPOUND | LPAR1, LPAR2, LPAR3 | KMT2A 668/4885TET3 4861/4885FBXL19 954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.