Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.75 |
| ▸ | TYK2 | P29597 | 3/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.57 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.57 |
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ebselen Diselenide SCHEMBL10520791 | 0.86 | METAP2 (1.00) | METAP2HTTALDH1A1POLBNPC1 | |
| SCHEMBL27946675 | 0.86 | JAK2 (0.77) | TYK2JAK2HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL10351942 | 0.83 | METAP2 (0.69) | METAP2HTTALDH1A1POLBGAA | |
| SCHEMBL9622275 | 0.82 | TYK2 (0.55) | METAP2TYK2JAK2HTTALDH1A1 | |
| SCHEMBL10520264 | 0.81 | METAP2 (0.77) | METAP2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL1499570 | 0.81 | NPC1 (0.70) | TYK2JAK2HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL8363543 | 0.81 | ALDH1A1 (0.55) | METAP2TYK2JAK2HTTALDH1A1 | |
| SCHEMBL10521616 | 0.80 | METAP2 (0.75) | METAP2ALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL10521106 | 0.80 | METAP2 (0.75) | METAP2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL10523571 | 0.80 | METAP2 (0.75) | METAP2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257306-B1 | DISELENOBIS BENZOIC ACID AMIDES OF PRIMARY HETEROCYCLIC AMINES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOUNDS COMPRISING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0257306-A1 | Diselenobis benzoic acid amides of primary heterocyclic amines, process for producing the same and pharmaceutical compounds comprising the same | A. Nattermann & Cie. GmbH (DE) | 1988-03-02 | — | — | EP | disclosed |