Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25184042 | 0.84 | TDP1 (0.43) | KMT2AMEN1RAB9APOLBBLM | |
| SCHEMBL30375688 | 0.84 | TDP1 (0.43) | KMT2AMEN1RAB9APOLBBLM | |
| SCHEMBL20786971 | 0.84 | TDP1 (0.55) | KMT2AMEN1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL25183263 | 0.82 | AKR1B1 (0.42) | KMT2AMEN1RAB9APOLBBLM | |
| SCHEMBL25183975 | 0.78 | NPBWR1 (0.54) | KMT2ARAB9ALMNAPKMNPC1 | |
| SCHEMBL30376079 | 0.78 | NPBWR1 (0.54) | KMT2ARAB9ALMNAPKMNPC1 | |
| SCHEMBL20786947 | 0.78 | NPC1 (0.46) | KMT2AMEN1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL20786950 | 0.78 | ALDH1A1 (0.48) | KMT2AMEN1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL18980285 | 0.77 | SMN1; SMN2 (0.73) | KMT2AMEN1RAB9APOLBBLM | |
| SCHEMBL18979949 | 0.76 | RAB9A (0.67) | KMT2AMEN1RAB9APOLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |