Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SOD1 | P00441 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10355346 | 0.98 | APP (0.42) | APPDHFRPDE10ACYP1A2CYP2C9 | |
| SCHEMBL10355551 | 0.92 | RAB9A (0.47) | PDE10ACYP1A2ALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10355414 | 0.91 | RAB9A (0.46) | PDE10ACYP1A2ALDH1A1NPC1RAB9A | |
| SCHEMBL10355379 | 0.84 | MAPT (0.57) | CYP1A2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL10355349 | 0.84 | SMN1; SMN2 (0.39) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL10355353 | 0.83 | SMN1; SMN2 (0.41) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| SCHEMBL10355350 | 0.81 | P2RX7 (0.38) | ALDH1A1TP53HPGDNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10355359 | 0.80 | SMN1; SMN2 (0.40) | ALDH1A1TP53HPGDNPC1RAB9A | |
| SCHEMBL10355620 | 0.80 | CCNB2 (0.37) | SMN1; SMN2MAPTIDO1CYP3A4KDM4E | |
| SCHEMBL10355380 | 0.80 | NPC1 (0.40) | CYP1A2CYP2C9CYP2C19HSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074130-B1 | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON S.p.A. (IT) | 1990-09-19 | — | — | EP | claimed |
| EP-0074130-B1 | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON S.p.A. (IT) | 1990-09-19 | — | — | EP | disclosed |
| US-4560696-A | Analgesic, antipyretic or anti-inflammatory imidazole compounds | ZAMBON S.P.A. (IT) | 1985-12-24 | — | — | US | disclosed |
| EP-0074130-A2 | New imidazole compounds, process for the preparation thereof and pharmaceutical compositions containing them | ZAMBON S.p.A. (IT) | 1983-03-16 | — | — | EP | disclosed |