Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | GRK6 | P43250 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | VDR | P11473 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | TYMP | P19971 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28289637 | 0.81 | PDGFRB (0.54) | DCUN1D1PIN1AURKANR1H2NR1H3 | |
| SCHEMBL10556612 | 0.81 | KDM4E (0.46) | AURKAMAPTSMN1; SMN2KDM4ETDP1 | |
| SCHEMBL20425457 | 0.80 | DCUN1D1 (0.52) | DCUN1D1PIN1AURKANR1H2NR1H3 | |
| SCHEMBL10099697 | 0.77 | PDGFRB (0.50) | DCUN1D1GRK6DYRK1ACLK4ADORA2A | |
| SCHEMBL7192429 | 0.77 | KIF11 (0.44) | PIN1DYRK1A | |
| SCHEMBL7254835 | 0.77 | IDO1 (0.46) | DYRK1A | |
| SCHEMBL2549690 | 0.76 | GRK6 (0.48) | GRK6DYRK1A | |
| SCHEMBL7146244 | 0.76 | NR1H2 (0.58) | DCUN1D1PIN1NR1H2NR1H3NR1I2 | |
| SCHEMBL672597 | 0.76 | NOTUM (0.42) | DCUN1D1PIN1NR1H2NR1H3CYP1A2 | |
| SCHEMBL15332174 | 0.75 | ALDH1A1 (0.56) | DCUN1D1PIN1AURKANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074130-B1 | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON S.p.A. (IT) | 1990-09-19 | — | — | EP | disclosed |