SCHEMBL1035543

SCHEMBL1035543

O=C(/C=C/c1cccc(Br)c1)C(=O)/C=C/c1cccc(Br)c1

nearest known ligand 0.79

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSD17B3 P37058 1/20 0.79
SLC6A19 Q695T7 1/20 0.61
BACE1 P56817 1/20 0.61
CYP2D6 P10635 1/20 0.59
CYP1B1 Q16678 1/20 0.59
PLAAT5 Q96KN8 1/20 0.58
PLAAT4 Q9UL19 1/20 0.58
PKM P14618 1/20 0.58
MAOB P27338 3/20 0.56
MAOA P21397 2/20 0.56
ALDH1A1 P00352 3/20 0.55
RELA Q04206 1/20 0.54
ATM Q13315 1/20 0.52
GPR55 Q9Y2T6 1/20 0.52
MAPT P10636 1/20 0.50
HTT P42858 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1035544 1.00 HSD17B3 (0.79) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
SCHEMBL29162914 0.91 HSD17B3 (0.71) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
SCHEMBL17157823 0.89 HSD17B3 (0.69) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
SCHEMBL17157819 0.89 HSD17B3 (0.69) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
Potassium Ion SCHEMBL17157820 0.89 HSD17B3 (0.69) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
SCHEMBL11586083 0.86 HSD17B3 (0.76) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
SCHEMBL11586088 0.86 HSD17B3 (0.76) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
SCHEMBL236623 0.86 HSD17B3 (0.76) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
SCHEMBL236624 0.86 HSD17B3 (0.76) HSD17B3SLC6A19BACE1CYP2D6CYP1B1
SCHEMBL31320929 0.86 HSD17B3 (0.76) HSD17B3SLC6A19BACE1CYP2D6CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8168307-B2 Organic compound, charge transport material and organic electroluminescent device PIONEER CORPORATION (JP) 2012-05-01 US disclosed
US-8168307-B2 Organic compound, charge transport material and organic electroluminescent device PIONEER CORPORATION (JP) 2012-05-01 US disclosed
EP-2275409-A1 Bipiridine derivative and organic electroluminescence element containing the same Yamagata Promotional Organization for Industrial Technology (JP) 2011-01-19 EP disclosed
EP-2275409-A1 Bipiridine derivative and organic electroluminescence element containing the same Yamagata Promotional Organization for Industrial Technology (JP) 2011-01-19 EP disclosed
US-20100327265-A1 BIPIRIDINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT CONTAINING THE SAME YAMAGATA PROMOTIONAL ORGANIZATION FOR INDUSTRIAL TECHNOLOGY (JP) 2010-12-30 US disclosed
US-20100327265-A1 BIPIRIDINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT CONTAINING THE SAME YAMAGATA PROMOTIONAL ORGANIZATION FOR INDUSTRIAL TECHNOLOGY (JP) 2010-12-30 US disclosed
US-20100327265-A1 BIPIRIDINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT CONTAINING THE SAME YAMAGATA PROMOTIONAL ORGANIZATION FOR INDUSTRIAL TECHNOLOGY (JP) 2010-12-30 US disclosed
US-20090021146-A1 ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE PIONEER CORPORATION (JP) 2009-01-22 US disclosed
US-20090021146-A1 ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE PIONEER CORPORATION (JP) 2009-01-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090021146-A1 ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE SLC25A21, SLCO2A1, OCIAD2 HSD17B3 2485/4885SLC6A19 392/4885BACE1 3515/4885
US-20100327265-A1 BIPIRIDINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT CONTAINING THE SAME NFE2L2, SLC19A2, AOC2 HSD17B3 2739/4885SLC6A19 56/4885BACE1 4174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.