Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355461 | 0.83 | ACHE (0.59) | ACHEKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6997956 | 0.77 | ACHE (0.54) | ACHEKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10355688 | 0.76 | ACHE (0.59) | ACHEKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6829957 | 0.76 | ACHE (0.52) | ACHEKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL171116 | 0.75 | ACHE (1.00) | ACHEKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10510029 | 0.72 | TUBB4A (0.55) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL11772869 | 0.72 | NPC1 (0.53) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| Boric Acid SCHEMBL4626813 | 0.71 | ACHE (0.81) | ACHEKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL13775501 | 0.71 | ACHE (0.58) | ACHEKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30785067 | 0.71 | KMT2A (0.53) | KMT2AMEN1ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207913-B1 | CATECHOL CARBOXAMIDES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES AND A PHARMACEUTICAL PREPARATION | Astra Läkemedel Aktiebolag (SE) | 1990-10-31 | — | — | EP | disclosed |
| EP-0207913-A1 | Catechol carboxamides, process for their preparation, intermediates and a pharmaceutical preparation | Astra Läkemedel Aktiebolag (SE) | 1987-01-07 | — | — | EP | disclosed |
| US-4499099-A | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | BEECHAM GROUP P.L.C. (GB) | 1985-02-12 | — | — | US | disclosed |
| US-4459300-A | ANTIEMETICS, GASTROINTESTINAL DISORDERS, CENTRAL NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | BEECHAM GROUP P.L.C. (GB) | 1984-07-10 | — | — | US | disclosed |
| EP-0069482-A1 | Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-01-12 | — | — | EP | disclosed |
| EP-0067615-A1 | Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1982-12-22 | — | — | EP | disclosed |