Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 17/20 | 0.70 |
| ▸ | WNT3A | P56704 | 12/20 | 0.70 |
| ▸ | TNKS | O95271 | 8/20 | 0.56 |
| ▸ | PARP1 | P09874 | 4/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.51 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.48 |
| ▸ | AXIN2 | Q9Y2T1 | 1/20 | 0.48 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1035001 | 0.91 | TNKS2 (0.68) | TNKS2WNT3ATNKSPARP1PARP2 | |
| SCHEMBL1033822 | 0.83 | TNKS2 (0.55) | TNKS2WNT3ATNKSPARP1PARP2 | |
| SCHEMBL7782072 | 0.83 | TNKS2 (0.71) | TNKS2WNT3ATNKSPARP1PARP2 | |
| SCHEMBL19074087 | 0.78 | TNKS2 (0.58) | TNKS2WNT3ATNKSPARP1PARP2 | |
| SCHEMBL1032368 | 0.75 | TNKS2 (0.52) | TNKS2WNT3ATNKSPARP1PARP2 | |
| SCHEMBL1032502 | 0.74 | TNKS2 (0.68) | TNKS2WNT3ATNKSPARP1HPGD | |
| SCHEMBL9070566 | 0.74 | TNKS (0.63) | TNKS2WNT3ATNKSPARP1HPGD | |
| SCHEMBL15661448 | 0.74 | HPGD (0.54) | TNKS2WNT3ATNKSPARP1MAPK1 | |
| SCHEMBL15660095 | 0.74 | LMNA (0.57) | TNKS2WNT3ATNKSPARP1MAPK1 | |
| SCHEMBL1034949 | 0.73 | TNKS2 (0.56) | TNKS2WNT3ATNKSPARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268845-B2 | Tetrahydro- and dihydroquinazolinones | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-8268845-B2 | Tetrahydro- and dihydroquinazolinones | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-8268845-B2 | Tetrahydro- and dihydroquinazolinones | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | FINSINGER DIRK | 2011-08-11 | — | — | US | disclosed |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | FINSINGER DIRK | 2011-08-11 | — | — | US | disclosed |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | FINSINGER DIRK | 2011-08-11 | — | — | US | disclosed |
| EP-1856061-B1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2011-01-26 | — | — | EP | disclosed |
| EP-1856061-B1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2011-01-26 | — | — | EP | disclosed |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
| EP-1856061-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | Merck Patent GmbH (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094604-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
| WO-2006094604-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, CSNK1E | TNKS2 682/4885WNT3A 2135/4885TNKS 461/4885 |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, DMPK | TNKS2 616/4885WNT3A 2243/4885TNKS 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.