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SCHEMBL10357664

SCHEMBL10357664

CCN(C(=O)CNS(=O)(=O)c1cccc2ccccc12)C(Cc1ccc(C(=N)N)cc1)C(=O)N1CCC(C)CC1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 9/20 0.57
▸ PLAU P00749 5/20 0.57
▸ PLG P00747 4/20 0.45
▸ F2 P00734 5/20 0.45
▸ ST14 Q9Y5Y6 2/20 0.45
▸ CCR10 P46092 1/20 0.42
▸ PRSS1 P07477 1/20 0.41
▸ PREP P48147 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10358239 0.82 F10 (0.56) F10PLAUPLGF2ST14
SCHEMBL10420196 0.72 F10 (0.54) F10PLAUPLGF2ST14
SCHEMBL10357661 0.71 F10 (0.62) F10PLAUPLGF2ST14
SCHEMBL7361857 0.68 F2 (0.58) F10PLAUPLGF2PRSS1
SCHEMBL1337015 0.68 F10 (0.68) F10PLAUPLGF2CCR10
SCHEMBL9061619 0.68 F10 (0.68) F10PLAUPLGF2CCR10
SCHEMBL7355389 0.67 F2 (0.59) F10PLGF2PREP
SCHEMBL9223678 0.66 F10 (0.51) F10PLAUPLGF2ST14
SCHEMBL8906075 0.66 F10 (0.51) F10PLAUPLGF2PRSS1
Hydrochloric Acid SCHEMBL6825808 0.65 F2 (0.56) F10PLAUF2CCR10PRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0236163-B1 DERIVATIVES OF N-ALPHA-SUBSTITUTED N-ALPHA-ARYLSULFONYLAMINOACYL P-AMIDINOPHENYLALANINAMIDES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THEIR INTERMEDIATES SANOFI (FR) 1990-10-03 — — EP claimed