SCHEMBL10358175

SCHEMBL10358175

C1=CC2Oc3c(-c4cccc(-c5c6ccccc6c(-c6ccccc6-c6ccc7ccccc7c6)c6ccccc56)c4)cccc3C2C=C1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 0.34
HDAC4 P56524 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HSD17B1 P14061 1/20 0.32
HSD17B2 P37059 1/20 0.32
GSTP1 P09211 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL179122 0.97 GPR84 (0.36) GPR84HDAC4HDAC2HDAC8HSD17B1
SCHEMBL10082723 0.96 HSD17B1 (0.35) GPR84HDAC4HDAC2HDAC8HSD17B1
SCHEMBL4186277 0.94 HSD17B1 (0.34) GPR84HDAC4HDAC2HDAC8HSD17B1
SCHEMBL20365304 0.92 GPR84 (0.34) GPR84HDAC4HDAC2HDAC8HSD17B1
SCHEMBL12640705 0.91 GPR84 (0.31) GPR84HSD17B1HSD17B2
SCHEMBL12640760 0.91 EDNRB (0.32) GPR84HDAC4HDAC2HDAC8
SCHEMBL12640765 0.91 GPR84 (0.34) GPR84HDAC4HDAC2HDAC8HSD17B1
SCHEMBL10069124 0.90
SCHEMBL1755412 0.89 GPR84 (0.31) GPR84
SCHEMBL179191 0.89 EDNRB (0.32) GPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120181922-A1 ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2012-07-19 US disclosed