Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10358690 | 0.87 | HTT (0.55) | HTTALDH1A1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL10359035 | 0.83 | PTGDR2 (0.48) | HTTALDH1A1GAAPTGDR2KDM4E | |
| Carbamic Acid SCHEMBL10358650 | 0.82 | HTT (0.64) | HTTALDH1A1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL10358552 | 0.81 | PTGDR2 (0.47) | HTTALDH1A1CYP1A2GAAPTGDR2 | |
| SCHEMBL5209901 | 0.80 | HTT (0.66) | HTTALDH1A1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL10358535 | 0.79 | HTT (0.73) | HTTALDH1A1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL5215600 | 0.79 | HTT (0.64) | HTTALDH1A1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL1362464 | 0.79 | HTT (0.64) | HTTALDH1A1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL1361173 | 0.77 | HTT (0.62) | HTTALDH1A1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL10359068 | 0.77 | CYP1A2 (0.76) | HTTALDH1A1CYP1A2GAAPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267986-B1 | \"(2-AMINO-4-ARYL-THIAZOLE-5-YL)ETHANOLS AND THEIR DERIVATIVES HAVING DIURETIC ACTIVITY AND METHODS FOR PREPARING THE SAME | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-11-22 | — | — | EP | claimed |
| US-4761422-A | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | LUSOFARMACO ISTITUTO LUSOFARMACO D'ITALIA SPA (IT) | 1988-08-02 | — | — | US | claimed |
| EP-0267986-A1 | \"(2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1988-05-25 | — | — | EP | claimed |
| EP-0267986-B1 | \"(2-AMINO-4-ARYL-THIAZOLE-5-YL)ETHANOLS AND THEIR DERIVATIVES HAVING DIURETIC ACTIVITY AND METHODS FOR PREPARING THE SAME | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| US-4761422-A | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | LUSOFARMACO ISTITUTO LUSOFARMACO D'ITALIA SPA (IT) | 1988-08-02 | — | — | US | disclosed |
| EP-0267986-A1 | \"(2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1988-05-25 | — | — | EP | disclosed |