SCHEMBL10358804

SCHEMBL10358804

C=CCC12C=CC(CC1OC(=O)Nc1ccccc1)C2

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.41
MC4R P32245 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAPK1 P28482 1/20 0.40
BCHE P06276 4/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
P2RX7 Q99572 2/20 0.36
CHRNA7 P36544 2/20 0.36
ACHE P22303 1/20 0.36
MAOB P27338 1/20 0.34
TGM2 P21980 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10359169 0.81
SCHEMBL10359171 0.77
SCHEMBL10359173 0.76 EPHX1 (0.40) LMNANPC1RAB9A
SCHEMBL10702361 0.70 MEN1 (0.39) LMNAL3MBTL1P2RX7TGM2
SCHEMBL9803151 0.70 TSHR (0.42) LMNAMC4RMAPK1NPSR1P2RX7
SCHEMBL11180684 0.67 BCHE (0.46) LMNAMC4RSMN1; SMN2MAPK1BCHE
SCHEMBL9803398 0.66 LMNA (0.45) LMNANPSR1
SCHEMBL9802748 0.66
SCHEMBL9802840 0.66
SCHEMBL11613244 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0226544-B1 Derivatives of alkyl-bicyclo[2.2.1]hept-5-ene-2-carboxylic acids CIBA-GEIGY AG (CH) 1990-03-07 EP disclosed
EP-0226544-A2 Derivatives of alkyl-bicyclo[2.2.1]hept-5-ene-2-carboxylic acids CIBA-GEIGY AG (CH) 1987-06-24 EP disclosed