Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 3/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10358550 | 0.87 | MEN1 (0.40) | KMT2AMEN1ALDH1A1MMEACE | |
| SCHEMBL4970309 | 0.83 | ALDH1A1 (0.48) | KMT2AMEN1ALDH1A1MMEACE | |
| SCHEMBL10358622 | 0.80 | ALDH1A1 (0.36) | KMT2AMEN1ALDH1A1ATMCA12 | |
| SCHEMBL4970642 | 0.75 | MEN1 (0.43) | KMT2AMEN1ALDH1A1MMEACE | |
| SCHEMBL10358499 | 0.71 | LMNA (0.45) | KMT2AMEN1ALDH1A1MMEACE | |
| SCHEMBL4970645 | 0.70 | MEN1 (0.57) | KMT2AMEN1ALDH1A1MMEACE | |
| SCHEMBL5087842 | 0.70 | MEN1 (0.55) | KMT2AMEN1ALDH1A1ATML3MBTL1 | |
| SCHEMBL15157179 | 0.70 | TP53 (0.61) | KMT2AMEN1ALDH1A1ATMCA12 | |
| SCHEMBL4969646 | 0.69 | POLB (0.61) | KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL4969816 | 0.69 | ELANE (0.38) | KMT2AMEN1ALDH1A1ATMPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243018-B1 | THIOLACTAM-N-ACETIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-10-24 | — | — | EP | disclosed |
| US-4771050-A | ALDOSE REDUCTASE INHIBITOR, ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0243018-A1 | Thiolactam-N-acetic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-10-28 | — | — | EP | disclosed |