Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5989854 | 0.89 | MAPT (0.72) | MAPTALDH1A1GPR174NPSR1LMNA | |
| SCHEMBL30783741 | 0.84 | MAPT (0.56) | MAPTALDH1A1GPR174NPSR1LMNA | |
| SCHEMBL957198 | 0.84 | MAPT (0.61) | MAPTALDH1A1GPR174NPSR1LMNA | |
| SCHEMBL3317301 | 0.83 | MAPT (0.81) | MAPTALDH1A1GPR174NPSR1LMNA | |
| SCHEMBL5322795 | 0.83 | ALDH1A1 (0.64) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL23884700 | 0.83 | MAPT (0.59) | MAPTALDH1A1GPR174LMNASMN1; SMN2 | |
| SCHEMBL22471138 | 0.82 | MAPT (0.62) | MAPTALDH1A1GPR174NPSR1LMNA | |
| SCHEMBL28038246 | 0.81 | ALDH1A1 (0.69) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL12890005 | 0.80 | GRM5 (0.62) | MAPTALDH1A1GPR174LMNASMN1; SMN2 | |
| SCHEMBL16823203 | 0.80 | MAPT (0.48) | MAPTALDH1A1GPR174NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257864-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-12-05 | — | — | EP | disclosed |
| US-4797401-A | 4-Substituted-1-(4-alkylsulphonamidophenyl)piperazines as antiarrhythmic agents | PFIZER INC. (US) | 1989-01-10 | — | — | US | disclosed |