Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278598 | 1.00 | MAPT (0.43) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL1278595 | 1.00 | MAPT (0.43) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL10840042 | 0.83 | MAPT (0.40) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL1278625 | 0.83 | MAPT (0.40) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL1278627 | 0.83 | MAPT (0.40) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL7343923 | 0.82 | SCN5A (0.40) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL1887617 | 0.82 | SCN5A (0.40) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL3501691 | 0.80 | TSHR (0.50) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL7369814 | 0.76 | TGM2 (0.38) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL7369817 | 0.76 | TGM2 (0.38) | MAPTNPC1RAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139614-B1 | PHARMACEUTICAL PREPARATIONS CONTAINING FLAVANONE OR THIOFLAVANONE DERIVATIVES, THE USE THEREOF, NOVEL FLAVANONES AND THIOFLAVANONES, AND PROCESSES FOR THEIR MANUFACTURE | Zyma SA (CH) | 1990-08-22 | — | — | EP | disclosed |
| US-4885298-A | Pharmaceutical preparations containing flavanone or thioflavanone derivatives the use thereof, novel flavanones and thioflavanones, and processes for their manufacture | ZYMA SA (CH) | 1989-12-05 | — | — | US | disclosed |
| EP-0096008-B1 | (+)-CYANIDAN-3-OL DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SUCH COMPOUNDS, AND THE USE OF THE LATTER | Zyma SA (CH) | 1989-03-29 | — | — | EP | disclosed |
| US-4644011-A | LIVER AND VIEN DISORDERS | ZYMA SA (CH) | 1987-02-17 | — | — | US | disclosed |
| US-4595677-A | Substituted tetrapeptides | CIBA-GEIGY CORPORATION (US) | 1986-06-17 | — | — | US | disclosed |
| US-4579684-A | Process for the manufacture of enol derivatives | CIBA-GEIGY CORPORATION (US) | 1986-04-01 | — | — | US | disclosed |
| US-4552871-A | ALDOSTERONE-ANTAGONISTIC, DIURETICS | CIBA GEIGY CORPORATION (US) | 1985-11-12 | — | — | US | disclosed |
| US-4510159-A | (+)-Cyanidan-3-ol derivatives, pharmaceutical preparations that contain such compounds, and the use of the latter to treat liver or venous diseases | ZYMA SA (CH) | 1985-04-09 | — | — | US | disclosed |
| EP-0115473-A2 | Substituted pyrrolidinone derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1984-08-08 | — | — | EP | disclosed |
| EP-0115472-A2 | Pyrrolidinon derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1984-08-08 | — | — | EP | disclosed |
| US-4405778-A | Process for preparing cephalosporin ethers | CIBA-GEIGY CORPORATION (US) | 1983-09-20 | — | — | US | disclosed |
| US-4319027-A | Process for the manufacture of ceohem enol derivatives | CIBA-GEIGY CORPORATION (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0045281-A1 | Triazoline derivatives and processes for their preparation | CIBA-GEIGY AG (CH) | 1982-02-03 | — | — | EP | disclosed |
| US-4313945-A | 7-Thiazolyl-acetamido-cephem derivatives with terminal aminocarboxylic acid grouping | CIBA-GEIGY CORPORATION (US) | 1982-02-02 | — | — | US | disclosed |
| US-4301278-A | BY HYDROGENATION IN THE PRESENCE OF A CATALYST | CIBA-GEIGY CORPORATION (US) | 1981-11-17 | — | — | US | disclosed |
| US-4293462-A | Process for the manufacture of enol derivatives, and intermediates | CIBA-GEIGY CORPORATION (US) | 1981-10-06 | — | — | US | disclosed |
| US-4256739-A | 7β-Amino-3-thio-3-cephem-4-carboxylic acid compounds, and antibacterial compositions and methods using them | CIBA-GEIGY CORPORATION (US) | 1981-03-17 | — | — | US | disclosed |
| US-4255328-A | CEPHALOSPORINS | CIBA-GEIGY CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4110533-A | PROCESS FOR THE MANUFACTURE OF ENOL DERIVATIVES | CIBA-GEIGY CORPORATION (US) | 1978-08-29 | — | — | US | disclosed |
| US-4073902-A | ANTIMICROBIAL COMPOUNDS | CIBA-GEIGY CORPORATION (US) | 1978-02-14 | — | — | US | disclosed |