Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | GLA | P06280 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10362966 | 0.85 | KDM4E (0.46) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL10361721 | 0.82 | ALDH1A1 (0.55) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL10362968 | 0.82 | KDM4E (0.46) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL10361540 | 0.81 | KDM4E (0.63) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL10362961 | 0.80 | KDM4E (0.48) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL7222086 | 0.80 | CA12 (0.53) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL25085840 | 0.79 | KDM4E (0.47) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL13316524 | 0.79 | LMNA (0.47) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL21580842 | 0.78 | ADORA1 (0.43) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL21580872 | 0.76 | CYP4F2 (0.50) | KDM4EGAAGLAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157346-B1 | QUINOLIZINONE COMPOUND, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-01-31 | — | — | EP | disclosed |
| US-4698349-A | Quinolizinone compounds, and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| US-4650804-A | TETRAZOLYLCARBAMOYL DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-17 | — | — | US | disclosed |
| EP-0157346-A2 | Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-10-09 | — | — | EP | disclosed |