Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355098 | 0.91 | TYK2 (0.45) | TYK2JAK2CYP3A4JAK1PTGS2 | |
| SCHEMBL21174718 | 0.89 | ITGB1 (0.47) | TYK2JAK2CYP3A4JAK1PTGS2 | |
| SCHEMBL21174715 | 0.89 | ITGB1 (0.47) | TYK2JAK2CYP3A4JAK1PTGS2 | |
| SCHEMBL28581212 | 0.86 | CASP3 (0.41) | TYK2JAK2CYP3A4JAK1PTGS2 | |
| SCHEMBL28581214 | 0.86 | CASP3 (0.41) | TYK2JAK2CYP3A4JAK1PTGS2 | |
| SCHEMBL18855169 | 0.85 | TLR7 (0.45) | TYK2JAK2CYP3A4JAK1ITGB1 | |
| SCHEMBL28444888 | 0.84 | TAS1R3 (0.48) | TYK2JAK2CYP3A4JAK1PTGS2 | |
| SCHEMBL18642732 | 0.84 | TYK2 (0.48) | TYK2JAK2CYP3A4JAK1PTGS2 | |
| SCHEMBL28468149 | 0.83 | TYK2 (0.53) | TYK2JAK2CYP3A4JAK1PTGS2 | |
| SCHEMBL20061313 | 0.82 | ITGB1 (0.43) | PTGS2ITGB1ITGA4ITGA2ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840505-B2 | Solid forms of (S)-3-(1-(9H-purin-6-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1 (2H)-one and methods of use thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-RE46621-E1 | Processes for preparing isoquinolinones and solid forms of isoquinolinones | INFINITY PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |
| US-20160152619-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | HCR COLLATERAL MANAGEMENT, LLC | 2016-06-02 | — | — | US | disclosed |
| US-9290497-B2 | Processes for preparing isoquinolinones and solid forms of isoquinolinones | INFINITY PHARMACEUTICALS, INC. (US) | 2016-03-22 | — | — | US | disclosed |
| US-20140371450-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | HCR COLLATERAL MANAGEMENT, LLC | 2014-12-18 | — | — | US | disclosed |
| US-8809349-B2 | Processes for preparing isoquinolinones and solid forms of isoquinolinones | INFINITY PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20120184568-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | HCR COLLATERAL MANAGEMENT, LLC | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152619-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | PIK3CA, PIK3CD, PDPK1 | TYK2 632/4885JAK2 116/4885CYP3A4 323/4885 |
| US-20120184568-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | PIK3CA, PDPK1, AKT3 | TYK2 972/4885JAK2 196/4885CYP3A4 373/4885 |
| US-20140371450-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | PIK3CA, PDPK1, AKT3 | TYK2 972/4885JAK2 196/4885CYP3A4 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.